Amorepacific Corporation

Pacific Corporation

Yung Hyup Joo

Song Seok Shin

Kyung Min Lim

Heung Soo Baek

Jin Kwan Kim

Yeon Su Jeong

Hong-Ju Shin

Young Ho Park

Jin Kyu Choi

Ho Sik Rho

John Hwan Lee

Yong Jin Kim

Jeong Hwan Kim

Jon Hwan Lee

Chang Seok Lee

Young-Ho Park

Mi Jin Park

Yong Deog Hong

Hyun Jung Shin

Yongjin Kim

Jae Won Yoo

Jung Bum Yi

Joo Hyun Moh

Min-Soo Noh

Jun-Yong Ha

Chae Wook Kim

Soo Jeong Choi

Chang Hoon Lee

Sang Jun Lee

Seo Young Kim

Hyung Jun Lim

Byoung Young Woo

Hyun Ju Koh

Se Jin Yoo

Jee Woo Lee

Ki-Wha Lee

Shin Chung

Hae Kwang Lee

Hyeung Geun Park

Young Ger Suh

Uh Taek Oh

Hee Doo Kim

Il Hong Bae

Kyoung Hee Byoun

Chang Geun Yi

Mi Hyun Oh

Kyung Mi Joo

Mi Young Park

Dae-Bang Seo

Ok Hui Park

Sun Young Kim

Young Im Oh

Young Joo Byun

Ji Young Kim

Seon Hwa Kang

Byeong Yung Woo

Seon-Hwa Kang

Yong Sil Lee

Jeong Ah Hwang

Yang Hui Park

Jun Won Yun

Young Hoon Choi

The present invention relates to a composition containing a bean extract extracted by low-concentration, low-grade alcohol or fractions thereof. The composition exhibits excellent effects in improving blood circulation, improving obesity, and preventing diabetes, hyperlipidemia and the like, and exhibits the effects of alleviating or treating the symptoms of diabetes, hyperlipidemia, and the like. The present invention also relates to a method for improving blood circulation and vascular health.

Composition containing a bean extract for improving blood circulation and vascular health and method for improving blood circulation and vascular health

In one aspect of the present specification, provided is a method for predicting a side effect of a whitening ingredient, the method comprising measuring at least one of i) the increase in toxicity according to long-term use of a whitening ingredient, ii) the difference between a concentration having whitening effect and a concentration having cell toxicity, and iii) the increase in sensitivity to the whitening ingredient according to ultraviolet pretreatment. In addition, the method has an effect of effectively predicting whether a side effect will occur if the whitening ingredient is used for a long time.

Method for predicting side effect of whitening ingredient

The present invention relates to a method for preparing a benzoic acid amide compound in a high yield by presenting a novel method for preparing a benzyl amine compound to be used as a reactant and delimiting the reaction condition of each step by using the same, and the method is economically advantageous since mass production is possible.

Method for preparing benzoic acid amide compound

Disclosed is a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. Also disclosed is a method for preparing a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. The novel adamantane derivative compound or the like has an excellent anti-androgenic effect.

Adamantane derivative compound

The present invention relates to a pseudo-ceramide compound and a preparation method therefor. According to the present invention, the pseudo-ceramide compound has a molecular structure and a function similar to those of a natural ceramide, can be readily synthesized, and has excellent solubility in an organic solvent and excellent stability, and thus the pseudo-ceramide compound can be used as an alternative to a natural ceramide. Therefore, the pseudo-ceramide compound of the present invention can be widely applied to a skin preparation for external use, a cosmetic composition, and the like for reinforcing and maintaining a skin barrier function.

Pseudo-ceramide compound and preparation method therefor

The present invention relates to a composition which can effectively control bacteria by containing meso-2,3-butanediol, which is an isomer of 2,3-butane diol, and has excellent antiseptic power even without containing a chemical antiseptic agent.

Composition containing meso-2,3-butanediol

Disclosed are a novel benzoic acid amide derivative compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof, or a solvate thereof. The novel compound and the like inhibit melanin production, prevent tyrosinase activity, and have an excellent skin whitening effect.

Benzoic acid amide compound

The present invention relates to a pseudo-ceramide compound and a method for preparing the same. The pseudo-ceramide compound of the present invention may provide antioxidant effects, and exhibits improved properties such as high solubility compared to existing natural ceramides and pseudo-ceramide compounds, and therefore, may be included in large quantities in the formulation. Accordingly, the pseudo-ceramide compound may be used in various fields such as cosmetics, medicinal substances, external preparations and foods.

5-Adamantan-1-yl-N-(2,4-dihydroxybenzyl)-2,4-dimethoxybenzamide disclosed in the present disclosure lacks toxicity and can exhibit superior anti-inflammatory effect. It exhibits superior anti-inflammatory effect, for example, by inhibiting the production of one or more of NO and PGE2, by inhibiting the activity of one or more of the transcription factors NF-&#x3ba;B and AP-1 or by inhibiting proinflammatory cytokines such as IL-1&#x3b2;.

Composition for anti-inflammation containing 5-adamantan-1-yl-N-(2,4-dihydroxy-benzyl)-2,4-dimethoxy-benzamide

The present invention relates to a novel benzoic acid amide derivative compound, isomers thereof, pharmaceutically acceptable salts thereof, prodrugs thereof, hydrates thereof, or solvates thereof. The novel compound has excellent skin whitening effects.

Disclosed is a novel compound acting as a cannabinoid receptor 1 inhibitor, the compound being a pyrazolo[1,5-a]pyrimidine derivative, a prodrug thereof, an isomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof. The novel compound or the like is useful for preventing or treating diseases mediated by the cannabinoid receptor-1.

Compound acting as a cannabinoid receptor-1 inhibitor

The present invention relates to an antithrombotic composition comprising a colored-bean extract or a fraction of the extract. The antithrombotic composition is highly useful for the treatment of diseases of the circulatory system, including cardiovascular disease, cerebrovascular disease, arteriosclerosis, hypertension and diabetes, which are caused by thrombosis.

Composition containing colored-bean extract

The present invention relates to novel thiourea derivatives as a modulator for vanilloid receptor (VR) and the pharmaceutical compositions containing the same. As diseases associated with the activity of vanilloid receptor, pain acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fervescence, stomach-duodenal ulcer, inflammatory bowel disease and inflammatory diseases can be enumerated. The present invention provides a pharmaceutical composition for prevention or treatment of these diseases.

Thiourea derivatives and the pharmaceutical compositions containing the same

The present invention provides a novel class of 4,5-diaryl-3(2H)-furanone derivatives, which inhibit strongly and selectively COX-2 over COX-1. They are useful to treat inflammation, inflammation-associated disorders, and COX-2 mediated diseases.

4,5-diaryl-3(2H)-furanone derivatives as cyclooxygenase-2 inhibitors

The diarylbenzopyran derivatives represented by formula I, and the pharmaceutically acceptable salts thereof, are disclosed. The composition comprising the compound of formula I, or a pharmaceutically acceptable salt thereof, shows an excellent selective inhibition of cyclooxygenase-2.

Diarylbenzopyran derivatives as cyclooxygenase-2 inhibitors

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Yongin-si, South Korea

Yung Hyup Joo