Yale University

University of Georgia Research Foundation Inc

Other

The University of North Carolina at Chapel Hill

The State University of New York

Emory University

University of Iowa Research Foundation

Health Research, Inc.

Epoch Pharmaceuticals, Inc.

Vion Pharmaceuticals, Inc.

Biotech Research Laboratories

Research Foundation of State of N.y.

Yung-Chi Cheng

Chung K Chu

Shwu-Huey Liu

Zaoli Jiang

Kuo-Hsiung Lee

Balakrishna S Pai

Tai-Shun Lin

Thomas J Bardos

Robert Tilton

Masanori Baba

Hiromichi Tanaka

Fucheng Qu

Alan C Schroeder

Hui-Kang Wang

Kenneth F Bastow

Alan C Sartorelli

Simon M Efange

Dennis C Liotta

Raymond F Schinazi

Eugeny Alexander Lukhtanov

Lieping Chen

Xin Guo

Michael W Reed

Woo-Baeg Choi

Rich B Meyer, Jr

Lan Xie

Yueh-Hsiung Kuo

James H Zhou

Yongseok Choi

Gang-Qing Yao

Ling Li

Hosup Yeo

Yi-Lin Zhang

Tai-Shun Lin, Deceased

Gang-Oing Yao

Ivan C King

Su-Ying Liu

Yoshiki Kashiwada

Mark Manak

Hong Hu

Louis Mark Cosentino

Sheau-Farn Yeh

David J Austin

Mario Sznol

Chen-Kung Chou

Chien-Neng Chang

Wing Lam

Yashang Lee

Juliang Zhu

Lei Fu

Yonglian Zhu

Miroslav Bobek

Masami Mori

Yao H Kuo

Dora M Schnur

J Phillip Bowen

Zhe Oing Wang

Zhe-Qing Wang

Xiao-Ming Zhou

Fu-Shen Han

Mao-Chin Liu

Jang-Yang Chang

Hong-Xing Chen

Terrance W Doyle

Ya-Ching Shen

Yongseok Chai

Robert Kilkulskie

Jing-Xi Xie

This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.

Herbal composition PHY906 and its use in chemotherapy

The invention relates to methods of evaluating the quality of a batch of an herbal composition, the method comprising subjecting a test batch of the herbal composition to one or more biological analysis methods and comparing the results derived from the test batch to the results of a known batch of herbal composition which has a known in vivo effect.

Mechanism based quality control for botanical medicine

In one embodiment, the present invention is directed to a composition comprising an aqueous or ethanolic extract of at least one herb selected from the group consisting of(:F3),L. (:B6),(:C4),Schneid. (:D8),(:S6),(:I2),L. (:F1),L. (:F5), andL. (:E5),var.(Mast.) Kitamura (:PE) and. (:PG), and mixtures thereof. The composition is administered to a patient, in an effective amount, in a method of treating, inhibiting, preventing, reducing the incidence of, ameliorating or resolving a disease state or condition caused in part or exacerbated by hyperactivity of the androgen receptor (AR), by inhibiting the androgen receptor protein. These compositions may also be used inhibit or stabilize hair loss or grow hair in a subject in need.

Inhibition of androgen receptor by extracts of medicinal herbs and compositions thereof

The present invention includes a method of using PHY906 for treating a bowel disorder including inflammatory bowel disease and irritable bowel syndrome. Particularly, the present invention provides a multiple symptoms treatment for the bowel disorder.

Use of PHY906 as treatment for inflammatory bowel disease and/or irritable bowel syndrome

The present invention relates to novel compounds according to the general formulas I, II, III, IV or V: wherein B is nucleoside base according to the structure: and the remaining variables as defined in the specification, and pharmaceutical compositions comprising the compounds. The compounds are useful interalia as anti-viral agents in viral therapy.

Anti-viral nucleoside analogs and methods for treating viral infections, especially HIV infections

This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of cancer by administering the herbal composition PHY906 in combination with one or more chemotherapeutic compounds to a mammal undergoing such chemotherapy.

Use of the combination of PHY906 and a tyrosine kinase inhibitor as a cancer treatment regimen

The present invention relates to the use of the compound according to formula (I), below for the treatment of tumors, cancer and hyperproliferative diseases, among other conditions or disease states: Where X is H or F; Rand Rare independently H, an acyl group, a C-Calkyl or ether group, a phosphate, diphosphate, triphosphate or a phosphodiester group, a (A) or (B) group; Where Nu is a radical of a biologically active compound such as an anticancer, antiviral or antihyperproliferative compound such that an amino group or hydroxyl group from said biologically active agent forms a phosphate, phosphoramidate, carbonate or urethane group with the adjacent moiety; each Ris independently H, or a C-Calkyl or ether group, preferably a C-Calkyl group; k is 0-12, preferably, 0-2; and pharmaceutically acceptable salts thereof. 

Methods of treating cancer and other conditions or disease states using LFMAU and LDT

Growing community of inventors

Woodbridge, CT, United States of America

Yung-Chi Cheng