Chung Yuan Christian University

University of Washington

J. Adams & Associates Limited

Other

National Central University

Hsu & Overmatt Co., Ltd.

J. Adams Associates Limited

Yung Chang

Shaoyi Jiang

Zheng Zhang

Juin-Yih Lai

Shengfu Chen

Wen-Yih Chen

Yu-Ju Shih

Ruoh-chyu Ruaan

Da-Ming Wang

Jheng-Fong Jhong

Bor-Shiunn Lee

Ching-Wei Tsai

Shia-Chung Chen

Yi-Hua Fan

Ruoh-Chyu Ruaan

Wen-Tyng Li

Ging-Ho Hsiue

Yaw-Jen Chang

Yan-Wen Chen

Ming-Fa Hsieh

Wei-Liang Liao

Ching-En Chen

Ching-Wei Huang

Ying-Ming Liang

Sheng-Han Chan

Wen-Lin Lin

Chuan-Hui Lu

Yen-Che Chiag

Akon Higuchi

Yan-Che Chiang

Chih Chen Yeh

Shenghan Chan

Wenlin Lin

Jhengfong Jhong

A platelet filtration membrane and its application for preparing platelets rich plasma and separating platelets from blood samples are disclosed. The platelet filtration membrane comprises a coating layer and a porous substrate. The coating layer composition comprises a first copolymer having a plurality of amide groups and a second copolymer having a plurality of carboxylic acid groups, and the porous substrate comprises PE, PP, PS, PET, PTFE, PVDF, ceramic or rayon. The coating layer is on surfaces of the porous substrate to form the platelet filtration membrane.

Platelet filtration membrane and its applications thereof

This invention is about a cell-penetrating drug carrier and the application thereof. The mentioned cell-penetrating drug carrier can approach the target cell through using a proper recognizable sequence, so that the cell-penetrating drug carrier can be used to specifically delivery wanted drug to target cell. Through carrying wanted drug into the cytoplasm of the target cell by cell-penetrating peptide, the drug accumulation volume in the target cell can be efficiently increased. Preferably, through using proper bioinert polymer, the cell-penetrating peptide and the recognizable sequence can be kept from been digested before approaching the target cell.

Cell-penetrating drug carrier and the application thereof

Nanoparticles zwitterionic polymers grafted thereto or grafted therefrom, and methods for making and using the nanoparticles. Zwitterionic nanogels, and methods for making and using the nanogels.

Particles coated with zwitterionic polymers comprising sulfobetaine or carboxybetaine

The present invention discloses an amine modifying material which is a copolymer polymerized from an amine functional acrylate, a poly(ethylene glycol) functional acrylate and a cross-linker. The application of the amine modifying material in the bio-molecules separation area is also provided in the present invention.

Amine modifying material and application thereof

The present invention discloses a biocarrier for delivery of a bioactive substance near/into a target cell, comprising a bioactive substance-loaded core with a first electricity, and one or more block copolymer, each block copolymer comprising a zwitterionic block and an anchoring block with an initial electricity opposite to the first electricity, wherein the anchoring block binds to the core by electrostatic attraction, and the zwitterionic block extends outwardly to increase the biocarrier stability in mammalian blood. Additionally, the present invention also discloses a method of using the biocarrier.

Biocarrier and method of using the same

The present invention provides an antibiofouling composition, an antibiofouling membrane and a method for forming the same. The antibiofouling composition comprises a copolymer and at least one solvent. The copolymer comprises at least one hydrophobic segment and at least one antibiofouling segment where the hydrophobic segment comprises a plurality of hydrophobic moieties and the antibiofouling segment comprises a plurality of antibiofouling moieties. The molar ratio of the total of hydrophobic moieties to the total of the antibiofouling moieties is 0.5&#x2dc;6.0.

Antibiofouling composition, antibiofouling membrane and method for forming the same

A dental care product comprises an orally acceptable carrier or excipient, and a bacterial resistance copolymer, which comprises a zwitterionic block and a charged anchoring block, wherein the anchoring block binds to tooth surfaces by electrostatic attraction, and the zwitterionic block extends outwardly to reduce the attachment of bacteria to tooth surfaces.

Dental care product with two-part formulations and utility thereof

The present invention discloses a system for testing microfluid which is made with a disposable disc. The high sensitivity, high sensing accuracy, and quick response microfluidic disc is demonstrated in the present invention. It is note that easy to test microfluid without traditional detecting method, and then reduce energy and simplify procedure. Furthermore, to additive the microfluidic disc is useful to enhance blood typing, and hence raising the sensitivity by the video recognition of blood agglutination.

Microfluid testing system with a multiple-channel disc and utility thereof

The invention provides a zwitterionic-bias material for blood cell selection, being a copolymer formed by zwitterionic structural units and charged structural units wherein the zwitterionic structural unit comprises at least one positively charged moiety and one negatively charged moiety, a distance between the positively charged moiety and the negatively charged moiety is a length of 1&#x2dc;5 carbon-carbon bonds, and the zwitterionic structural units and charged structural units are randomly arranged to have zwitterionic-bias.

Zwitterionic-bias material for blood cell selection

Dental care product

This invention discloses a surface anti-biomolecule agent for an artificially or naturally charged substrate. The anti-biomolecule agent comprises a copolymer employing anchoring blocks or domains to binds sites of the substrate via electrostatic attractive force, and employing zwitterionic blocks or domains extended outwardly to reduce the attachment of biomolecules to the substrate.

Surface anti-biomolecule agent

Super-low fouling sulfobetaine and carboxybetaine materials, super-low fouling surfaces and methods of making the surfaces coated with sulfobetaine and carboxybetaine materials, and devices having the super-low fouling surfaces.

Super-low fouling sulfobetaine materials and related methods

The present invention discloses statistical antibiofouling nonionic-zwitterionic copolymers. The antibiofouling nonionic-zwitterionic copolymers are with the LCST (Lower Critical Solution Temperature) and/or UCST (Upper Critical Solution Temperature), and with increasing content of the nonionic monomers, the LCST and/or UCST of copolymers varies.

Antibiofouling nonionic-zwitterionic copolymer

The present invention discloses a method for forming a low biofouling filtration membrane. First, an ozone treatment is performed to a fluorine-based porous membrane to introduce peroxides on surface. Afterwards, a first grafting polymerization is initiated from the peroxides, and functional monomers are polymerized to introduce halide groups on surface. Finally, a second grafting polymerization is initiated from the halide groups, and macro-monomers are polymerized to introduce zwitterionic group on surface, so as to form the low biofouling filtration membrane.

Low biofouling filtration membranes and their forming method

Super-low fouling sulfobetaine and carboxybetaine materials and related methods

Growing community of inventors

Taipei, Taiwan

Yung Chang