Shanghai Synergy Pharmaceutical Sciences Co., Ltd.

Zhejiang Huahai Pharmaceutical Co., Ltd.

Suzhou Tergar Iot Technology Co., Ltd

Yunfei Li

Yijin Wang

Jian Ge

Zhen Zhang

Xin Xu

Jiamiao Wang

Xiaoer Xia

Xiaojuan Zhang

Liming Zhang

Lei Liu

Jia Chen

Dongsheng Li

Zhiyun Wang

Qingyun Jiang

Dengxue Sun

Linli Zhang

Lihong Lin

Fengying Guo

Qiang Li

Fan Yang

Guan Zhong Wang

Qiang Liu

Hao Yu

Jing Su

Tao Cheng

Xiaobo Zhou

Kang Sun

Fuming Huang

Junning Huang

Hualin Cai

Chenghao Xi

Chunqiao Chen

Yuyun Zhang

Minkai Qu

Jinqian Song

Qimei Wu

Chengxu Zang

Qiang Zhang

Provided are amide compounds, a preparation method therefor, and use thereof in the medical field. Specifically, provided are small molecule amide compounds. Such compounds are inhibitors of enhancer of Zeste homolog 2 (EZH2), and can be used for preventing and/or treating related diseases mediated by EZH2, including tumors, myeloproliferative diseases or autoimmune diseases.

Amide compounds, preparation method therefor, and use thereof in the medical field

Related are a JAK kinase inhibitor, a preparation method for same, and applications thereof in the field of medicine, related to the field of medicinal chemistry. Provided is a novel small molecule JAK inhibitor, which has the structure as represented by formula (II). The compound provides improved efficacy and safeness in preventing or treating a JAK-related indication.

JAK kinase inhibitor, preparation method for same, and applications thereof in field of medicine

A powder injection of a donepezil semi palmoxiric acid salt, a composition containing the same and a preparation method therefor. The powder injection contains donepezil semi palmoxiric acid salt crystals having an average particle size of 2-52 &#x3bc;m.

Powder injection of the donepezil semi palmoxiric acid salt, composition containing same and preparation method therefor

A powder injection of a donepezil semi palmoxiric acid salt, a composition containing the same and a preparation method therefor. The powder injection contains donepezil semi palmoxiric acid salt crystals, and the average grain size of the crystals ranges from 0.5 &#x3bc;m to 100 &#x3bc;m.

Disclosed are a class of &#x3bc;-opioid receptor agonists and a preparation method therefor and the use thereof in the field of medicine, belonging to the field of medicinal chemistry. The &#x3bc;-opioid receptor agonists significantly increase the selectivity for a G protein signaling pathway, and not only can exhibit excellent pharmacodynamic effects, but also significantly improve safety.

&#x3bc;-opioid receptor agonist and preparation method therefor and use thereof in field of medicine

The present application provides a vortioxetine pamoic acid salt, which includes a crystal form, a solvate or an amorphous substance of the vortioxetine pamoic acid salt. The present application provides a preparation method and use of the vortioxetine pamoic acid salt and the crystal form thereof. The vortioxetine pamoic acid salt prepared in the present application prolongs the residence time of the vortioxetine in vivo, achieving a slow release of the vortioxetine in vivo, and is suitable for preparing a long-acting dosage form.

Vortioxetine pamoic acid salt and crystal form thereof

Provided are a compound of the formula below, and a pharmaceutically acceptable salt or stereoisomer thereof that can be used for treating cardiovascular diseases and compositions containing the compounds. The compounds, a pharmaceutically acceptable salt or stereoisomer thereof and the compositions can improve lipid metabolism disorders by increasing high-density lipoprotein cholesterol in blood; in addition, the compounds, a pharmaceutically acceptable salt or stereoisomer thereof and the compositions can also release nitric oxide, and reduce the onset risk of cardiovascular diseases by means of relaxing blood vessels, lowering blood pressure, inhibiting platelet adhesion and aggregation and maintaining vascular tension, and thus play an important role in preventing and treating the occurrence and development of cardiovascular diseases. 

Nitric oxide-releasing prodrug molecule of substituted quinazolines

A center-mounted control system for a bicycle includes a torsion detector, a torque transducer, first and second wireless transceiving units, and a control unit. The torsion detector is sleeved on a crank shaft and detects a torque signal of the crank shaft and transmit the detected torque signal to the torque transducer; the torque transducer is fixedly connected to the torsion detector and senses the torque signal transmitted from the torsion detector and sends the torque signal to the first wireless transceiving unit; the control unit receives and processes the torque signal and controls an electrical motor according to the processed torque signal; and a first clutch of the bicycle is sleeved on the crank shaft and is fixedly connected to one end, close to a chain ring, of the torsion detector, and the first clutch of the bicycle is fixedly connected to the chain ring.

Center-mounted control system of bicycle

Growing community of inventors

Shanghai, China

Yunfei Li