Institute of Pharmacology and Toxicology Academy of Military Medical Sciences Pla China

Beijing Molecule Science and Technology Co., Ltd.

Institute of Pharmacology and Toxicology Academy of Military Medical Science P.l.a. China

Peking University

Academy of Military Medical Sciences

Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.l.a.

Beijing Molecule Science Technology Co., Ltd.

Hunan Nanxin Pharmaceutical Co., Ltd.

Yunde Xie

Song Li

Junhai Xiao

Wu Zhong

Zhibing Zheng

Xingzhou Li

Xinbo Zhou

Lili Wang

Xiaokui Wang

Guoming Zhao

Hongying Liu

Hao Cui

Wei Chen

Hongliang Wang

Xian Wei Zhang

Ruiyuan Cao

Cheng Xu

Fei Xie

Mingming Zhao

Dian Xiao

Guangqiang Xia

Chengmai Ruan

Cuifang Lin

Wei Li

Ying Wang

Yang Zhang

Gang Cheng

Yao Liu

Jing Yan Ma

Jing Su

Bing Zhang

Yanming Wang

Bing Li

Qi Sun

Ping Liu

Hongqiang Wang

Long Long

Dan Jiang

Zhong Wu

Feifei Li

Dan Han

Dalong Ma

Hui Qi

Jing Ma

Boqun Lyu

Haoming Luo

Hongwei Gong

Xiaomei Ling

Meina Li

Enquan Xu

Xiaoqian Xu

Hua Guan

Yanbo Yang

Zhibing Zhen

Shiyong Fan

Xiaoye Zhang

Libao Xu

Fangyuan Cao

Xian Zhang

The present application relates to a linker containing arylnitro, an antibody-drug conjugate the linker and use of the linker, as well as a pharmaceutical composition comprising the antibody-drug conjugate and use of the antibody-drug conjugate for treatment and/or prevention of a disease

Linker containing arylnitro, antibody-drug conjugate containing linker and use of linker

Disclosed in the present invention is a compound of Formula (I), a geometric or optical isomer, a pharmaceutically acceptable salt, a solvate or a polymorph thereof. Also disclosed in the present invention is a composition comprising the compound of Formula (I), the geometric or optical isomer, the pharmaceutically acceptable salt, the solvate or the polymorph thereof. Also disclosed in the present invention is a use of the compound of Formula (I), the geometric or optical isomer, the pharmaceutically acceptable salt, the solvate or the polymorph thereof in the treatment of a disease or disorder such as a hypoglutamatergic condition, a neurodegenerative disease or respiratory depression, particularly in the treatment of a disease or disorder associated with AMPA receptor. 

Brain-targeting prodrug for AMPA receptor synergist, and pharmaceutical applications thereof

The present invention relates to a 2,3-epoxy succinyl derivative, a preparation method and a use thereof, in particular, the present invention relates to a compound represented by Formula (1), a racemate or an optical isomer thereof, a solvate thereof, or a pharmaceutically acceptable salt thereof. The compound according to the present invention has good inhibitory activity and/or selectivity against cathepsin, especially Cathepsin B, can be used in the treatment of multiple diseases associated with cathepsin, for example, osteoporosis, rheumatoid arthritis and osteoarthritis that are associated with Cathepsin K, Ebola virus infection, a degenerative disease and an autoimmune disease that are associated with Cathepsin L, S, especially Cathepsin B-related tumor diseases, such as gastric cancer, cervical cancer, lung cancer, breast cancer, prostate cancer, bladder cancer, colon cancer, neuroglioma, and melanoma. 

2,3-epoxy succinyl derivative, preparation method and use thereof

The present invention relates to a compound represented by Formula I, a racemate or optical isomer thereof, or a pharmaceutically acceptable salt, a solvate or a hydrate thereof, a pharmaceutical composition comprising the compound, and a use thereof in the manufacture of a medicament for preventing and/or treating a disease or disorder associated with a viral infection. 

4-oxo-4,5-dihydrothiazole derivative, preparation method and use thereof

The invention belongs to the technical field of medicines. In particular, the invention relates to a thiazideamide derivative compound or a pharmaceutically acceptable salt or solvate thereof, a pharmaceutical composition comprising the compound or a pharmaceutically acceptable salt or solvate thereof, a method for preparing the compound or a pharmaceutically acceptable salt or solvate thereof, and a use of the compound or a pharmaceutically acceptable salt or solvate thereof. For example, the compound or a pharmaceutically acceptable salt or solvate thereof according to the invention can be used to prevent and/or treat a neurodegenerative disease or a neuropathic disease caused by a physical trauma or a related disease.

Thiazideamide derivative and use thereof

The present invention pertains to the field of pharmaceutical chemicals, and relates to a substituted acethydrazide derivative, preparation method and use thereof; preferably, relates to a compound of Formula I or a pharmaceutically acceptable salt thereof. The compound of the present invention or a pharmaceutically acceptable salt thereof can effectively inhibit proline hydroxylase, stabilize HIF-&#x3b1;, particularly HIF-1&#x3b1;, and has potency in the manufacture of a medicament for treatment and/or prophylaxis and/or adjuvant therapy of anemia, acute ischemic reperfusion injury. 

Substituted acethydrazide derivative, preparation method and use thereof

The invention relates to tizoxanide phosphate or alkane sulfonate compounds represented by Formula I, and pharmaceutically acceptable salts thereof, isomers thereof, hydrates thereof or solvates thereof, and pharmaceutical applications of the compounds. 

Tizoxanide phosphate and alkane sulfonate and pharmaceutical applications thereof

The invention relates to a tizoxanide carbamate compound of Formula I and a pharmaceutically acceptable salt, a hydrate or a solvate thereof, and their pharmaceutical use. 

Tizoxanide carbamate and pharmaceutical use thereof

The invention relates to a homoserine lactone derivative of Formula I, preparation method and use thereof. The compound has an effect of regulatory of bacterial quorum sensing, and is useful for preventing and/or treating a disease caused by infection of a bacterium 

N-sulfonyl homoserine lactone derivatives, preparation method and use thereof

The invention relates to a compound of formula I, and a preparation method and use thereof. The compound has a bacterial quorum-sensing regulatory effect, and can be used for prevention and/or treatment of a disease caused by a bacterial infection. 

Bacterial quorum sensing regulator and medical use thereof

Provided are a compound of formula I which can be used as a drug against small RNA virus infections, and optical isomers, pharmaceutically acceptable salts, solvates or hydrates thereof. Also provided are the preparation method of the compound, the method for using the compound for treating bacterial infections and the use of the compound in the preparation of a drug for preventing and/or treating viral diseases caused by small RNA viruses. 

2,3-butanediamide epoxide compound and preparation method and use thereof

A derivative of homoserine lactone represented by formula I, and a preparation method and use thereof. The compound has a bacterial quorum-sensing regulatory effect, and can be used for prevention and/or treatment of a disease caused by a bacterial infection. 

Derivative of homoserine lactone, and preparation method and use thereof

Disclosed are pyridazine derivatives represented by Formula I or pharmaceutically acceptable salts or hydrates thereof, pharmaceutical compositions comprising the compounds, methods of treating and/or preventing diseases or disorders associated with viral infections in patients using the compounds, and the use of the compounds in preparing the medicaments for treating and/or preventing diseases or disorders associated with viral infections. The compounds represented by Formula I have antiviral activity, especially anti-microRNA viral activity. Symbols in the compounds represented are described in the specification. 

Pyridazine derivatives and use thereof as medicaments for treating microRNA viral infection

The present invention relates to (1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-guanidino-2-hydroxy-cyclopentyl-1-carboxylic acid hydrates compounds, preparing methods thereof, pharmaceutical compositions containing said compounds and preparing methods thereof, and the clinical uses of said compounds as neuramidinase inhibitors for anti-influenza.

(1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-uanidino-2-hydroxyl-cyclopentyl-1-carboxylic acid hydrates pharmaceutical uses thereof

Provided are piperazinyl pyrimidine derivatives of formula I having CCRantagonism, and the preparation method, pharmaceutical composition and use thereof in the preparation of a medicament. The medicament is useful for the treatment and prevention of CCR-related diseases. 

Piperazinyl pyrimidine derivatives, preparation method and use thereof

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Yunde Xie