University of Michigan

Omega Optics, Inc.

Other

Yunbo Guo

Ray T Chen

Xudong Fan

Swapnajit Chakravarty

Theodore B Norris

James R Baker, Jr

Lingjie Jay Guo

Jing Yong Ye

Maung Kyaw Khaing Oo

Harish Subbaraman

Nils Walter

Karthik Reddy

James R Baker

Methods and systems for highly-sensitive label-free multiple analyte sensing, biosensing, and diagnostic assay are disclosed. The systems comprise an on-chip integrated two-dimensional photonic crystal sensor chip. The invention provides modulation methods, wavelength modulation and intensity modulation, to monitor the resonance mode shift of the photonic crystal microarray device and further provides methods and systems that enable detection and identification of multiple species to be performed simultaneously with one two-dimensional photonic crystal sensor chip device for high throughput chemical sensing, biosensing, and medical diagnostics. Other embodiments are described and claimed.

Two-dimensional photonic crystal MicroArray measurement method and apparatus for highly-sensitive label-free multiple analyte sensing, biosensing, and diagnostic assay

Two-dimensional photonic crystal microarray measurement method and apparatus for highly-sensitive label-free multiple analyte sensing, biosensing, and diagnostic assay

3-dimensional surface-enhanced Raman scattering (SERS), as well as absorption/fluorescence/luminescence detection is carried out using a platform based on nanoparticle-functionalized flow-through multi-hole capillaries for rapid analyte detection. The configuration provides an increased active area and fluidic channels for efficient sample delivery, and also confines and transmits light for a large signal accumulation. Using a capillary consisting of thousands of micron-sized holes adsorbed with gold nanoparticles, a detection limit better than 100 fM is achieved.

SERS, fluorescence, absorption, and luminescence detection with flow-through multi-hole capillaries

A photonic crystal-metallic (PCM) structure receives an input light signal from a light source. The PCM structure includes a metal structure and a photonic crystal structure disposed adjacent the metal structure. The photonic crystal structure is configured to receive the input light signal such that the input light signal excites surface plasmons of the metallic structure and such that the input light signal is internally reflected within the photonic crystal structure.

Photonic crystal-metallic structures and applications

Devices, methods and systems based on integrated photonic crystal structures are disclosed. An integrated photonic crystal structure includes a photonic crystal structure and a defect member disposed adjacent the photonic crystal structure. The defect member includes a photoconductive material. The integrated photonic crystal structure is configured to receive an input light signal such that the input light signal is internally reflected within the photonic crystal structure and the defect member, such that the input light signal is absorbed by the photoconductive material in the defect member, and such that a property of the photoconductive material is changed to thereby output an output signal.

Integrated photonic crystal structures and their applications

A self-referencing composite Fabry-P&#xe9;rot cavity sensor, including methods of use and manufacture. The cavity sensor comprises a substrate defining a first cavity portion juxtaposed to a second cavity portion. The first and second cavity portions are provided having a predetermined depth offset. A polymer or other dielectric material is disposed within the first and second cavity portions. An interference spectrum resulting from a light source of a known wavelength is reflected through the sensor and produces a first refractive index from the first cavity portion offset by a second refractive index from the second cavity portion. The difference in refractive indices can be used to determine various physical parameters. An optical sensor according to the present technology may be used with vapor sensing, pressure sensing, protein detection, photo-acoustic imaging, and the like.

Composite Fabry-P&#xe9;rot sensor

A photonic crystal sensor for outputting an output signal using a light source. The photonic crystal sensor includes a photonic crystal structure and a defect member disposed adjacent the photonic crystal structure. The defect member defines an operative surface. An input light signal from the light source is inputted to the photonic crystal structure and defect member and is internally reflected to thereby output the output signal. Also, the output signal relates to a condition at the operative surface.

Growing community of inventors

Austin, TX, United States of America

Yunbo Guo