Abbott Cardiovascular Systems, Inc.

Advanced Cardiovascular Systems, Inc.

Medtronic Minimed, Inc.

Yunbing Wang

James Oberhauser

David C Gale

Xiao Ma

Stephen D Pacetti

Thierry Glauser

Bin Huang

Lothar W Kleiner

Kathleen Yan

Mikael Trollsas

Syed Faiyaz Ahmed Hossainy

Vincent J Gueriguian

Manish Gada

Luis Sucy Vazquez

Ni Ding

Daniel A Castro

Kevin Jow

Arlene Sucy Yang

Michael H Ngo

Byron Lambert

Syed F A Hossainy

David K Wrolstad

Rommel Lumauig

Garth L Wilkes

Hung T Nguyen

Hugh Zhao

Scott H Mueller

Bethany Steichen

John Joseph Stankus

Florian Ludwig

Fuh-Wei Tang

Derek Mortisen

Gregory Kilinski

Benjamyn Serna

Klaus Kleine

Svava Maria Atladottir

Richard Rapoza

Dan Castro

Benny Serna

Jonathan D Halderman

John S Stankus

Jhoan Bayogo

Rajiv Shah

Udo Hoss

Timothy A Limon

William P Van Antwerp

Syed F Hossainy

Dariush Davalian

Bruce M Wilson

Jenn-Hann Larry Wang

Matthew J Gillick

Justin K Mann

Pamela A Kramer-Brown

Brooks B Cochran

Bioabsorbable scaffolds having high crush recoverability, high fracture resistance, and reduced or no recoil due to self expanding properties at physiological conditions are disclosed. The scaffolds are made from a random copolymer of PLLA and a rubbery polymer such as polycaprolactone.

Shape memory bioresorbable polymer peripheral scaffolds

A medical device includes a polymer stent crimped to a catheter having an expansion balloon. The stent is crimped to the balloon by a process that includes heating the stent to a temperature below the polymer's glass transition temperature to improve stent retention without adversely affecting the mechanical characteristics of the stent when later deployed to support a body lumen. A variable diameter sheath with a central portion that prevents expansion of the stent when the balloon is pressurized and larger diameter ends is disposed over the crimped stent-balloon assembly. The balloon is pressurized and the larger diameter ends of the sheath allow the balloon beyond the ends of the stent to expand. The balloon is then depressurized.

Method of increasing stent retention of bioabsorbable scaffolding with a sheath

An apparatus and method for controlling inflation pressure, pressurization rate, and volumetric flow rate of a balloon during deployment of a stent or scaffold is disclosed.

Flow regulation valve for controlling inflation rate of a balloon deploying a scaffold

A medical device-includes a scaffold crimped to a catheter having an expansion balloon. The scaffold is crimped to the balloon by a process that includes one or more balloon pressurization steps. The balloon pressurization steps are selected to enhance scaffold retention to the balloon, maintain a relatively uniform arrangement of balloon folds about the inner surface of the crimped scaffold so that the scaffold expands in a uniform manner when the balloon is inflated, and to avoid any possible over-stretching of balloon material.

Method of uniform crimping and expansion of medical devices

Methods and systems for controlling the moisture content of biodegradable and bioresorbable polymer resin during extrusion above a lower limit that allows for plasticization of the polymer resin melt and below an upper limit to reduce or prevent molecular weight loss are disclosed. Methods are further disclosed involving plasticization of a polymer resin for feeding into an extruder with carbon dioxide and freon.

Controlling moisture in and plasticization of bioresorbable polymer for melt processing

Methods of treating a diseased blood vessel exhibiting stenosis with a bioabsorbable stent are disclosed. The implanted stent supports the section of the vessel at an increased diameter for a period of time to allow the vessel to heal. The stent loses radial strength sufficient to support the section of the vessel in less than 6 months after implantation, loses mechanical integrity, and then erodes away from the section. The biodegradable stent results in changes in properties of plaque with time as the stent degrades. The time-dependent properties include the luminal area of the plaque and plaque geometric morphology parameters.

Bioabsorbable stent and treatment that elicits time-varying host-material response

Implantable medical devices fabricated from branched polymers are disclosed.

Implantable medical devices fabricated from branched polymers

A medical device includes a polymer stent scaffold crimped to a catheter having an expansion balloon. A process for forming the medical device includes placing the scaffold on a support supported by an alignment carriage, and deionizing the scaffold to remove any static charge buildup on the scaffold before placing the scaffold within a crimper to reduce the scaffold's diameter. The polymer scaffold is heated to a temperature below the polymer's glass transition temperature to improve scaffold retention without adversely affecting the mechanical characteristics of the scaffold when deployed to support a body lumen.

Methods for crimping a polymeric stent scaffold onto a delivery balloon

A biodegradable polymeric stent made from poly(L-lactide) and a low concentration of L-lactide monomer is disclosed. The concentration of L-lactide is adjusted to provide a degradation behavior that is suitable for different treatment applications including coronary, peripheral, and nasal.

Biodegradable stent with adjustable degradation rate

Methods of treating with a biodegradable polymeric stent made from poly(L-lactide) and a low concentration of L-lactide monomer is disclosed. The concentration of L-lactide is adjusted to provide a degradation behavior that is suitable for different treatment applications including coronary, peripheral, and nasal.

Method of making a poly(L-lactide) stent with tunable degradation rate

A medical device-includes a polymer stent crimped to a catheter having an expansion balloon. The stent is crimped to the balloon by a process that includes heating the stent to a temperature below the polymer's glass transition temperature to improve stent retention without adversely affecting the mechanical characteristics of the stent when later deployed to support a body lumen.

Methods for crimping a polymeric stent onto a delivery balloon

Bioabsorbable polymer scaffolds with coatings are disclosed that include immobilized antithrombotic agents on the scaffolds or in or on the coatings. The agents act synergistically with antiproliferative agents released from coatings by providing hemocompatibility during and without interfering with antiproliferative agent release. Methods of modifying scaffolds and coatings with the antithrombotic agents are disclosed.

Modification of bioabsorbable stent to reduce thrombogenecity

Stent scaffolds comprising branched biocompatible polymers are disclosed.

Growing community of inventors

Sunnyvale, CA, United States of America

Yunbing Wang