Tsinghua University

Hydata

Annoroad Gene Technology (beijing) Co., Ltd

Zhejiang Annoroad Bio-technology Co. Ltd.

Yun Xia

Xin Li

Cheng Liu

Yi Xu

Ke Wang

Meng Zhao

Yonghui Zhang

Dawei Li

Liping Li

Bai Yang

Zhaoling Xuan

Junbin Liang

Chongjian Chen

Yicun Feng

Yonghua Xie

Zhengsen Yu

Xiaoying Zhou

Yuan Fan

Yujie Zhang

Longhui Li

Wanli Liu

Zhandong Wang

Yunyun Yang

Kanzhao Gao

Yuehan Xue

Disclosed are inhibitors of mevalonate pathway as an efficient vaccine adjuvant and use thereof. In particular, the inhibitor is an acetoacetyl-CoA transferase inhibitor, a HMG-CoA synthase inhibitor, a HMG-CoA reductase inhibitor, a mevalonate kinase inhibitor, a phosphomevalonate kinase inhibitor, a mevalonate-5-pyrophosphate decarboxylase inhibitor, an isopentenyl pyrophosphate isomerase inhibitor, a farnesyl pyrophosphate synthase inhibitor, a geranylgeranyl pyrophosphate synthase inhibitor or a geranylgeranyl transferase (I, II) inhibitor. Also disclosed is an immunogenic composition comprising inhibitors of mevalonate pathway as an adjuvant.

Mevalonate pathway inhibitor as highly-efficient vaccine adjuvant

A method according to one embodiment includes importing a plurality of resources associated with an entity, receiving, from the entity, a request for an application that performs predetermined functionality, creating a functionality definition, utilizing the request, determining, from the plurality of resources associated with the entity, one or more necessary resources for implementing the functionality definition, constructing the application that performs the predetermined functionality, utilizing the one or more necessary resources, and implementing the application in an environment of the entity.

Open platform for providing ability to end users

Growing community of inventors

Beijing, China

Yun Xia