City University of Hong Kong

Versitech, Inc.

Yun Wah Lam

Chi-Ming Che

Hongyan Sun

Tai Chu Lau

Doris Wai Ting Au

Wai Lun Man

Hong Juan Dong

Wen Xiu Ni

A method of determining a cell cycle stage distribution of cells includes the steps of providing a cell sample; pre-treating the cell sample with a solvent; mixing the pre-treated cell sample with a matrix solution to obtain a mixture solution; depositing the mixture solution on a sample plate; obtaining a mass spectrum analysis of the deposited mixture solution; and identifying at least two marker peaks from the mass spectrum analysis, wherein a ratio between the marker peaks provides information about a cell cycle stage distribution of the cell sample, wherein the mass spectrum analysis is a matrix-assisted laser desorption/ionization time-of-flight mass spectrum test.

Method of determining cell cycle stage distribution of cells

In various embodiments, a pharmaceutical composition comprising an effective amount of a peptide having the amino acid sequence represented by Formula (I) or an analog thereof, and a pharmaceutically tolerable excipient is described. In some embodiments, the analog of the peptide of Formula (I), comprises the peptide sequence of Formula (I) wherein one or more of the amino acids residues are modified by a) C-terminal modification; b) D-amino acid substitution; and/or c) deletion of one or more amino acid residues. A method of inhibiting the growth of a microorganism comprising contacting the microorganism in a medium with an effective amount of the peptide of Formula (I) or an analog thereof is also described, as are similar methods of treating a disease or disorder associated with microbial activity in a subject by administering an effective amount of a peptide of Formula (I) or an analog thereof and a pharmaceutically tolerable excipient to the subject.

Antimicrobial peptide, its analog and use

The invention relates to nitridoosmium complexes and methods of using these compounds as treatments for cancer.

Nitridoosmium(VI) complexes for treatment of cancer

Growing community of inventors

Hong Kong, China

Yun Wah Lam