Daewoong Pharmaceutical Co., Ltd.

Yun Soo Yoon

Joon Seok Park

Mi Ryeong Han

Kyung A Yu

Ji Duck Kim

Jun Hee Lee

Min Hee Cho

Sun Young Kim

Ha Young Kim

In Woo Kim

Yeon Jung Song

Sun Ah Jun

Hyo Shin Kim

Min Jae Cho

Hyung Geun Lee

Yun Soo Na

Kang-Pil Kim

Kyung Ha Chung

The present invention relates to a compound having a blocking effect against sodium ion channels, particularly Nav1.7, a preparation method thereof and the use thereof. A compound represented by formula 1 according to the invention, or a pharmaceutically acceptable salt, hydrate, solvate or isomer thereof may be effectively used for the prevention or treatment of pain, for example, acute pain, chronic pain, neuropathic pain, post-surgery pain, migraine, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neuropathic disease, epilepsy, arrhythmia, myotonia, ataxia, multiple sclerosis, irritable bowel syndrome, urinary incontinence, visceral pain, depression, erythromelalgia, or paroxysmal extreme pain disorder (PEPD).

Sodium channel blockers, preparation method thereof and use thereof

Disclosed are novel triazole derivatives. Exhibiting excellent antifungal activity and in vivo safety, they are useful for the treatment or prevention of fungal infections caused by a wide spectrum of fungi.

Antifungal triazole derivatives

The present invention relates to triazole derivaties, a method for the preparation thereof, and a pharmaceutical composition containing the same as an active ingredient. The inventive triazole derivaties have an excellent antifungal activity against various pathogens.

Antifungal triazole derivatives, method for the preparation thereof and pharmaceutical composition containing same

Disclosed herein are antifungal triazole derivatives or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition comprising the same. The triazole derivatives of Chemical Formula 1 or pharmaceutically acceptable salts thereof according to the present invention have excellent inhibitory activity against a broad spectrum of fungi, in addition to being safe to the body, and thus are very useful in the treatment and prevention of fungal infection.

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Seoul, South Korea

Yun Soo Yoon