Daewoong Pharmaceutical Co., Ltd.

Yun Soo Na

Min Hee Cho

Ji Duck Kim

Jun Hee Lee

Joon Seok Park

In Woo Kim

Ha Young Kim

Sun Ah Jun

Mi Ryeong Han

Chang Min Park

Youn Jung Yoon

Yun Soo Yoon

Hyo Shin Kim

Ho Bin Lee

Min Jae Cho

Hyung Geun Lee

Kyung Ha Chung

Yeon Jung Park

The present invention relates to novel oxodihydropyridinecarbohydrazide derivatives with excellent antifungal activities, an antifungal composition containing the same, and its use for the prevention and treatment of fungal infectious diseases. The oxodihydropyridinecarbohydrazide derivatives of the present invention have excellent antifungal and fungicidal activities, and thus will be useful for the prevention and treatment of various fungal infections byspp.,spp.,andspp., etc. Additionally, the oxodihydropyridinecarbohydrazide derivatives of the present invention, unlike other fungicidal preparations, can be orally administered.

Antifungal oxodihydropyridinecarbohydrazide derivative

The present invention relates to a compound having a blocking effect against sodium ion channels, particularly Nav1.7, a preparation method thereof and the use thereof. A compound represented by formula 1 according to the invention, or a pharmaceutically acceptable salt, hydrate, solvate or isomer thereof may be effectively used for the prevention or treatment of pain, for example, acute pain, chronic pain, neuropathic pain, post-surgery pain, migraine, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neuropathic disease, epilepsy, arrhythmia, myotonia, ataxia, multiple sclerosis, irritable bowel syndrome, urinary incontinence, visceral pain, depression, erythromelalgia, or paroxysmal extreme pain disorder (PEPD).

Sodium channel blockers, preparation method thereof and use thereof

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Gyeonggi-do, South Korea

Yun Soo Na