Ewha University-Industry Collaboration Foundation

Aptabio Therapeutics Inc.

Yun Soo Bae

Kee In Lee

Sun Myung Choi

Soo Young Lee

Jee Hyun Lee

Mi Sun Seo

Hye Rin Bin

Do Min Lee

Sung Hwan Moon

Sung Chan Lee

Gyoon Hee Han

Soo Jin Lee

Hun Joo Ha

Gil-Ja Jhon

Jin Joo Cha

Jin-Kyung Limb

Kyung Hee Song

So-Yeop Han

Jung-Yeon Yoo

Jae Sang Kim

Dae Ryong Cha

Young Sun Kang

Disclosed is a pharmaceutical composition for preventing or treating a fatty liver disease containing, as an active ingredient, a pyrazole-based compound or a pharmaceutically acceptable salt thereof. 3-phenyl-4-alkyl-1-(pyridin-2-yl)-1H-pyrazol-5-ol or a pharmaceutically acceptable salt thereof is capable of effectively inhibiting fatty liver, hepatic inflammation and hepatic fibrosis, and is useful for preventing or treating NAFLD, in particular, NASH.

Therapeutic agent for liver diseases

The present invention provides a composition for preventing or treating kidney disease, the composition comprising a pyrazole derivative compound or a pharmaceutically acceptable salt thereof; and the composition of the present invention is effective in reducing proteinuria, reducing cell formation between glomerular blood vessels and suppressing kidney fibrosis.

Composition for treating kidney disease comprising pyrazole derivative

The present invention provides pyrazole derivative compounds and pharmaceutically acceptable salts thereof. The compounds of the present invention have an excellent effect of preventing and treating osteoporosis.

Pyrazole derivatives, preparation method thereof, and composition for prevention and treatment of osteoporosis containing same

The present invention relates to a method for inducing the differentiation of CD34+ hematopoietic stem cells into megakaryocytes and platelets, more particularly, a method for inducing the differentiation of CD34+ hematopoietic stem cells into megakaryocytes and platelets comprising the steps of coculturing CD34+ hematopoietic stem cells with stromal cells and adding the compound of Formula 1. Further, the present invention relates to a composition for detecting the differentiation of hematopoietic stem cells into megakaryocytes and platelets, comprising an agent measuring expression level of a gene that is selected from the group consisting of KLF2 (Kiruppel-like factor2), LOC138255 (OTTHUMP00000021439), GDF15 (growth differentiation factor 15) and INHBE (inhibin, betaE), a kit comprising the composition, a method for detecting the differentiation into megakaryocytes and platelets by using the marker genes, a method for regulating the differentiation into megakaryocytes and platelets, and a method for screening a candidate compound that regulates the differentiation into megakaryocytes and platelets.

Methods for inducing the differentiation of hematopoietic stem cells into megakaryocytes and platelets, and gene controlling the differentiation

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Seongnam-si, South Korea

Yun Soo Bae