Glaxo Group Limited

Sap Se

Glaxosmithkline Intellectual Property Development Limited

Shanghai Simr Biotechnology Co., Ltd

Shanghai Simrd Biotechnology Co., Ltd

Astex Therapeutics Limited

Yun Jin

Zehong Wan

Wen-Syan Li

Qing Shan Zhang

Jian Wang

James Francis Callahan

Fei Wang

Jeffrey Charles Boehm

Alison Jo-Anne Woolford

Feng Ren

Charlotte Mary Griffiths-Jones

Thomas Daniel Heightman

Jeffrey K Kerns

Qian Liu

Hongxing Yan

David Norton

Xiao Ding

Nicole Cathleen Goodwin

Cheng Peng

Xiaomin Zhang

Baowei Zhao

Shuai Li

Weiqiang Xing

Yingxia Sang

Hailong Wang

Yuan Fang

Yimin Hu

Ami Lakdawala Shah

Yang Zhan

Qi Sun

Luigi Piero Stasi

Yong Sun

Tindy Li

Roderick S Davis

Leo Hu

Jinhua Wu

Nanyang Chen

Paris L Hamilton

Qing Zhang

The present invention discloses phthalazine isoxazole alkoxy derivatives, a preparation method thereof, a pharmaceutical composition, and a use thereof. The present invention provides a compound represented by Formula I, cis-trans isomers thereof, enantiomers thereof, diastereoisomers thereof, racemates thereof, solvates thereof, hydrates thereof, and pharmaceutically acceptable salts or prodrugs thereof. The compound has an excellent inverse agonist effect with respect to &#x3b1;5-GABA. 

Substituted [1,2,4]triazolo[3,4-a]phthalazines as modulators of GABAreceptor activity

Disclosed are substituted fused pyrazoles, for example substituted indazoles, that inhibit LRRK2 kinase activity, pharmaceutical compositions containing them and their use in the treatment of Parkinson's disease.

Substituted fused pyrazole compounds and their use as LRRK2 inhibitors

A query analyzer may be used to identify a plurality of queries and associated query characteristics, the query characteristics including a corresponding dataset of data units for each query, wherein the data units are to be loaded from an offline memory into a memory of an in-memory database. Then, a sequencer may be used to select a selected dataset for loading into the memory of the in-memory database, based on dependencies between the plurality of queries as included within the query characteristics, and on relationships, if any, between the datasets.

Data loading techniques for an in-memory database

The embodiments provide a federated system for supporting an application to perform analytics. The federated system includes a first distributed system for performing one or more first tasks including processing incoming data into a set of data blocks, an in-memory database system for performing one or more second tasks including receiving the set of data blocks from the first distributed system and storing the set of data blocks in an internal storage, and a second distributed system for performing one or more third tasks including receiving at least one data block of the set from the in-memory database system and performing analytics on the at least one data block. Execution of the first, second, and third tasks are controlled via a scripting language utilized by the application and associated with the in-memory database system.

Integrated analytics on multiple systems

The present invention relates to novel compounds that inhibit Lp-PLAactivity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA, for example atherosclerosis, Alzheimer's disease, and/or diabetic macular edema.

Pyrimidinone compounds for use in the treatment of diseases or conditions mediated by LP-PLA2

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Shanghai, China

Yun Jin