The University of Texas System

Yun Huang

Yubin Zhou

Lian He

Nhung T Nguyen

In an embodiment, a device for modulating intracellular gene expression, the device having a calcium actuator component and a transcription reprogramming component. In another embodiment, a method for modulating intracellular gene expression, where the method includes inducing a system having a calcium actuator component and a transcription reprogramming component with at least one of light and a chemical, causing an increase in Ca, and translocating the transcription reprogramming component from cytosol to the nucleus. In a further embodiment, a method for modulating gene intracellular expression, where the method includes inducing a system having an NIR-stimulable optogenetic platform with at least one of light and a chemical, where the NIR-stimulable optogenetic platform facilitates Carelease and the NIR-stimulable optogenetic platform is LOV2-SOAR, causing an increase in Ca, and translocating a calcium-responsive dCas9 fusion construct from cytosol to the nucleus, where the calcium-responsive dCas9 fusion construct is NFAT-dCas9-VP64.

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Houston, TX, United States of America

Yun Huang