Hutchison Medipharma Enterprises Limited

Hutchison Medipharma Limited

Generon (shanghai) Corporation Ltd.

Itabmed (hk) Limited

Yumin Cui

Wei-Guo Su

Xiaoqiang Yan

Weihan Zhang

Yongxin Ren

Jifeng Duan

Hong Jia

Yang Sai

Wenji Li

Zhenping Wu

Zhihua Huang

Haibin Yang

Zhenping Tian

Jiangyong Shao

Xinfeng Zhang

Hanyang Chen

Wuzhong Shen

Yiqun Rao

Bo Qi

The present invention provides bispecific antigen binding proteins (BSAPs) that specifically bind to CD3 and a tumor antigen (e.g., CD19). The present invention also provides uses of the BSAPs for the preparation of pharmaceutical compositions, methods of treating cancer, and kits comprising the BSAPs.

Anti-CD19 and anti-CD3 bispecific antigen binding proteins and uses thereof

The present invention provides multispecific Fab fusion proteins (MSFP) that specifically bind to CD3 and EpCAM. The present invention further provides uses of the MSFPs for the preparation of pharmaceutical compositions, methods of treating cancer, and kits comprising the MSFPs. Also provided are anti-EpCAM antibodies or antigen-binding fragments thereof.

Multispecific fab fusion proteins and use thereof

Provided are certain quinazoline compounds, compositions thereof and methods of use thereof. These quinazoline compounds can effectively inhibit the overexpression and/or overactivity of epidermal growth factor receptor (EGFR).

Quinazoline compounds

Compound of Formula A and pharmaceutically acceptable salts thereof and crystalline Forms I and II of Compound of Formula A! Also, methods for the preparation of such compounds, pharmaceutical compositions comprising such compounds, and methods for their uses.

Compound, certain novel forms thereof, pharmaceutical compositions thereof and methods for preparation and use

A compound of the following formula: wherein R, R, R, R4, R5, T, U, V, X, Y, Z, G, and Z are defined herein. It also discloses a method of treating an angiogenesis-related disorder, e.g., cancer or age-related macular degeneration, with such a compound.

Pyrimidine derivatives

Quinazoline derivatives of the following formula: wherein R, R, R, R, R, R, R, R, R, R, X, and Z are defined herein. It also discloses a method of treating an angiogenesis-related disorder with one of these compounds.

Use of substituted quinazoline compounds in treating age-related macular degeneration

Quinazoline derivatives of the following formula: wherein R, R, R, R, R, X, Y, and Z are defined herein. It also discloses a method of treating cancer with one of these compounds.

Quinazoline derivatives

Use of substituted quinazoline compounds in treating angiogenesis-related diseases

Substituted quinazoline compounds of the following formula: wherein R, R, R, R, R, R, R, R, R, R, and X are defined herein. It also discloses a pharmaceutical composition containing one of these compounds.

Substituted quinazoline compounds and their use in treating angiogenesis-related diseases

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Shanghai, China

Yumin Cui