Meiji Seika Kaisha, Ltd.

Yumiko Sambongi

Takashi Ida

Kunio Atsumi

Yuko Kano

Kazuhiro Aihara

Takahisa Maruyama

Takashi Ando

Katsuyoshi Iwamatsu

Toshiro Sasaki

Kiyoshi Tanabe

Hideo Kitagawa

Hiromasa Takizawa

Yoshihisa Akiyama

Kastuyoshi Iwamatsu

Carbapenum derivatives

Disclosed is a novel carbapenem derivative having a substituted imidazo&lsqb;5,1-b&rsqb;thiazole group at the 2-position on the carbapenem ring have high anti microbial activities against &bgr;-lactamase producing bacteria, MRSA, resistant- , PRSP, enterococci, and influenza, and high stabilities to DHP-1. According to the present invention, there is provided a compound represented by the formula (I), or a pharmacologically acceptable salt thereof or an ester at the 3-position on the carbapenem ring thereof:

Carbapenem derivatives

Disclosed is a novel carbapenem derivative having a substituted imidazo&lsqb;5,1-b&rsqb;thiazole group at the 2-position on the carbapenem ring have high anti-microbial activities against &bgr;-lactamase producing bacteria, MRSA, resistant- , PRSP, enterococci, and influenza, and high stabilities to DHP-1. According to the present invention, there is provided a compound represented by the formula (I), or a pharmacologically acceptable salt thereof or an ester at the 3-position on the carbapenem ring thereof:

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Yokohama, Japan

Yumiko Sambongi