Meiji Seika Kaisha, Ltd.

Other

Meji Seika Kaisha Ltd.

Yumiko Okada

Sachiko Miyamoto

Yasushi Murai

Yasuo Ohtsuka

Katsuharu Iinuma

Mami Kawaguchi

Kenichi Fushihara

Takashi Shishikura

Sohjiro Shiokawa

Toshio Nishizuka

Seiji Tsutsumi

Hideo Kitagawa

Toyoaki Ishikura

Hiromi Takata

Maki Shiobara

Osamu Sakanaka

Makoto Ohyama

Peter Jeschke

Norbert Mencke

Achim Harder

Seiji Shibahara

Gerhard Bonse

Masao Koyama

Toshio Yoneta

Shohei Yasuda

Tatsuo Watanabe

Masamichi Sukegawa

Masayuki Takagi

Shinjiro Sumi

Tadaaki Okada

Masaaki Takahashi

Maki Ohishi

Shin-Ichi Kitahara

Hanae Furukawa

Koreaki Imura

Toshihiro Yamaguchi

Shinichiro Tsujiyama

Maki Matsumoto

Hiroyuki Iwasawa

Disclosed is a process for efficiently producing a compound represented by formula (I): wherein Rrepresents aryl, amino, alkyl, or alkoxy; Rrepresents a protective group of the carboxylic acid; and Rrepresents an alkali metal, a hydrogen atom, alkyl, aryl, alkylsulfonyl, arylsulfonyl, or trialkylsilyl. This process is characterized by reacting a compound of formula (II) with a compound of formula (III) in the presence of a transition metal compound. 

Process for producing 1,2,3-Triazole compounds

Tricyclic triazolobenzazepine derivatives in the form or a prodrug are provided. The compounds according to the present invention are those represented by formula (I) and pharmacologically acceptable salts and solvates thereon. The compounds are useful as antiallergic agents and exhibit excellent bioavailability. wherein Rrepresents hydrogen, OH, alkyl or phenyl alkyl, 

Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic agents

A process for preparing a compound represented by formula (IIa')wherein Q represents group (i) as defined in the specification and Rto R, R, R, and Rare as defined in the specification, by (1) reacting a compound represented by formula (V)wherein Rto Rand Rare as defined in the specification. with a compound represented by RRC&#x2550;O wherein Rand Rare as defined in the specification; (2) reacting the compound prepared in (1) with a compound represented by R&#x2014;C(&#x2550;O)&#x2014;Rwherein Rand Reach independently represent a chlorine atom, 4-nitrophenyl, or 1-imidazolyl; and (3) reacting the compound prepared in (2) with a compound represented by ROH wherein Ris as defined in the specification.

Disclosed are novel crystalline 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5H),10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzazepine and a pharmaceutical composition comprising the same.

Crystalline tricyclic triazolobenzazepine derivative

Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic

Novel derivatives of PF1022 substance, which are cyclodepsipeptides represented by the general formula (I) shown below or their salts are useful as anthelmintic agent for prevention or treatment of parasitic infections.

Derivatives of cyclodepsipeptide PF1022 substance

There can be produced, at a high selectivity and in a high yield, the Z-isomer of a 7-N-unsubstituted or substituted-amino-3-&lsqb;2-(4-substituted or unsubstituted-thiazol-5-yl) vinyl&rsqb;-3-cephem-4-carboxylic acid or an ester thereof having the general formula (IV)

Process for the selective preparation of Z-isomers of 3-2(substituted vinyl)cephalosporins

Derivatives of cyclodepsipeptide PF 1022

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Odawara, Japan

Yumiko Okada