Ajinomoto Co., Ltd.

Ea Pharma Co., Ltd.

Yumiko Fukuda

Masaru Takayanagi

Satoru Okamoto

Naoyuki Fukuchi

Tadakiyo Nakagawa

Kazuyuki Sagi

Naoyuki Yamada

Takao Ikenoue

Takashi Kayahara

Masataka Shoji

Wataru Miyanaga

Sen Takeshita

Shunji Takehana

Naoko Arashida

Kaoru Yoshida

Akira Takahara

Mitsuo Takahashi

Masahiro Yamanashi

A method of screening a compound having a hypoglycemic effect (hereinafter referred to as 'hypoglycemic compound'), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the &#x3b2; subunit of a trimeric GTP-binding protein, a remedy for diabetes comprising a hypoglycemic compound, which is characterized by being capable of binding to the &#x3b2; subunit of a trimeric GTP-binding protein, as the active ingredient, etc.

Remedy for diabetes

Benzamidine derivatives of the following formulae or analogs thereof, i.e., pharmaceutically acceptable salts thereof, are provided. These compounds or salts thereof have a blood-coagulation inhibiting effect based on an excellent effect of inhibiting the action of activated blood coagulation factor X, and they are useful as anticoagulants 

Benzamidine derivatives

Benzamidine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof are provided. These compounds have an effect of inhibiting activated blood-coagulation factor X, and they are useful as agents for preventing or treating various diseases caused by thrombi or emboli.

Benzamidine derivative

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Kawasaki, Japan

Yumiko Fukuda