St Pharm Co., Ltd.

Yumi Ji

Moon Hee Kim

Kyeong-Eun Jung

Sungwon Kim

Kyung-Il Kim

Kyoung-Il Kim

Alexei Kayushin

The present invention provides a method for preparing nucleotide oligomers, including (a) coupling a nucleotide dimer or nucleotide trimer to a nucleoside attached to solid supports or to universal solid supports as a starting material; (b) sequentially coupling nucleotide monomers to the resulting structures of Step (a) to prepare a nucleotide oligomer; and (c) removing the nucleotide oligomers from the solid supports. The method of the present invention provides nucleotide oligomers having 15-20% higher purity than the conventional art. The present invention enables the efficient and inexpensive synthesis of nucleotide oligomers with high purity within a shorter period of time.

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Gunpo-si, South Korea

Yumi Ji