Memorial Sloan Kettering Cancer Center

Icahn School of Medicine at Mount Sinai

University of Rochester

Sloan-kettering Institute for Cancer Research

Mount Sinai School of Medicine

Genelux Corporation

Yuman Fong

Peter M Palese

Adolfo Garcia-Sastre

Qian Zhang

Aladar A Szalay

Yong A Yu

Howard J Federoff

Prasad S Adusumilli

Dmitriy Zamarin

Joseph D Rosenblatt

Peter Palese

Described herein are chimeric Newcastle disease viruses engineered to express a heterologous interferon antagonist and compositions comprising such viruses. The chimeric Newcastle disease viruses and compositions are useful in the treatment of cancer.

Chimeric newcastle disease viruses and uses thereof

Chimeric Newcastle disease viruses and uses thereof

An autologous vaccine to tumor cells is produced by transducing the tumor cells with a herpes simplex virus amplicon containing the gene for an immunomodulatory protein to provide transient expression of the immunomodulatory protein by the cells. The tumor cells may transduced with the herpes simplex amplicons ex vivo or in vivo. Suitable immunomodulatory proteins include cytokines, for example, interleukins, interferons, and chemokines such as RANTES; intercellular adhesion molecules, for example ICAM-1 and costimulatory factors such as B7.1. The tumor cells may also be transduced with one or more species of amplicon containing genes for two or more different immunomodulatory proteins.

Rapid production of autologous tumor vaccines

Growing community of inventors

New York, NY, United States of America

Yuman Fong