City of Hope

University of California

California Institute of Technology

Yuman Fong

Nanhai G Chen

Yu-Chong Tai

Colin A Cook

Xiwei Wu

Arthur X Li

Maria A Hahn

John H Yim

Yang Liu

Paul J Yazaki

Jack Shively

Michael Bouvet

Jonathan Delong

Saswati Chatterjee

Stephen J Forman

Saul J Priceman

Lily L Lai

Michael Storrie-Lombardi

Veronica Jones

Daniel Schmolze

Sun-Wing T R Tong

Ragini Kothari

Anthony K Park

The current disclosure provides, inter alia, method of determining benign nodules from thyroid cancer in a subject that is found to have a thyroid nodule, method of treating thyroid cancer in a subject detected to have thyroid cancer by the method of the current disclosure, compositions for determining benign nodules from thyroid cancer in a subject, and kits including reagents and composition for determining benign nodules from thyroid cancer in a subject.

Methods, treatment, and compositions for characterizing thyroid nodule

An oncolytic poxvirus encoding a truncated human CD19 is used in conjunction with a chimeric antigen receptor to treat solid tumors.

Oncolytic virus expressing a car T cell target and uses thereof

Disclosed is a tumor-specific antibody and fluorophore conjugate for detecting, localizing and imaging of various tumors. Also disclosed are methods for detecting, localizing and imaging a solid tumor before or during a tumor resection surgery using the antibody-fluorophore conjugate.

NIR-conjugated tumor-specific antibodies and uses thereof

Provided herein are, inter alia, viral compositions and methods of using the same. The viral compositions provided include, inter alia, therapeutically effective amounts of a chimeric poxvirus and are particularly useful for methods of treating cancer. The chimeric poxviruses provided herein may further include transgenes.

Chimeric poxvirus compositions and uses thereof

A cell cultivation apparatus for cultivating microorganisms and growing cells at high density is provided. The apparatus includes a membrane comprising multiple surface features on a first side of the membrane for cell placement. The surface features comprising one or more compartments within which a cell can be located. The membrane includes a material that is at least partially permeable to gas. A second side of the membrane defines a gas region. The second side of the membrane is separated from the first side of the membrane by the membrane. The apparatus further includes a media region for receiving media. The compartments are configured to at least partially reduce media flow shear forces on one or more cells in the compartments. The surface features may be ridges, protrusions, fins, wells, and/or posts.

System, device and method for production of bioproduct including high density cell respirator (HDCR) for intensified production of adeno-associated viruses (AAV) and cell-based production

Systems and methods are configured to detect and/or ablate cancerous tissue, such as during surgery. The system uses Laser Ramen Spectroscopy (LRS) or Surface Enhanced Raman Spectroscopy (SERS) to enhance a detection signal pursuant to a spectroscopy analysis of tissue. Rapid in situ detection of cancer can be combined with immediate laser thermal ablation of the cancerous tissue. The detection and ablation can occur before, during, or after surgical resection.

Cancer detection and ablation system and method

A polymer or other substrate optimized for growing cells is described, which takes the form of a micro-thin bag with gas permeable sides. Sides of the bag can be held at a fixed distance from one another with a multitude of tiny micropillars or other spacers extending between them, keeping the bag at a predetermined thickness and preventing the bag from collapsing and the sides from sticking together. In other embodiments, the sides may be held apart by gas pressure alone. A 0.01 &#x3bc;m to 1000 &#x3bc;m parylene or other biocompatible coating over the bag outsides controls the permeability of the bag material and provides a bio-safe area for cell growth. An alternate configuration uses open-cell foam with skins coated with a biocompatible coating. Tubes going into multiple bags can be connected to a manifold that delivers gaseous oxygen or removes carbon dioxide and other waste gases. Multiple bags can be stacked together tightly, with o-ring spacers in between, and housed within a vessel to form a high-surface area, ultra-compact cell growing system. For cells growing on the bags, liquid nutrients can be fed by way of the tube spacers, and oxygen and waste gases permeated through the bag sides and transported within the bags.

Substrates for high-density cell growth and metabolite exchange

The present subject matter provides, inter alia, a method of diagnosing invasive ductal cancer or detecting invasive ductal cancer risk in a subject who has ductal carcinoma in situ, a method of treating breast cancer in a subject detected to have invasive ductal cancer or determined to be at risk of invasive ductal cancer, compositions for detecting invasive presence or potential in ductal carcinoma in situ in a subject, and kits including reagents and composition for detecting invasive presence or potential in ductal carcinoma in situ in a subject.

DNA methylation diagnostic test for breast cancer

Disclosed are lighting and optical devices, systems, and methods for use in laparoscopic surgical procedures. The disclosed devices, systems, and methods advantageously do not require tethers in order to receive power or transmit data, such as camera images, to and from an external device. In addition, the disclosed devices, systems, and methods utilize improved camera mechanisms and reduce costs and improve accessibility with respect to laparoscopic surgical procedures.

Lighting and optics surgical system

Lighting and optical devices, systems, and methods are configured for use in laparoscopic surgical procedures. The disclosed devices, systems, and methods advantageously do not require tethers in order to receive power or transmit data, such as camera images, to and from an external device. In addition, the disclosed devices, systems, and methods utilize improved camera mechanisms and reduce costs and improve accessibility with respect to laparoscopic surgical procedures. Furthermore, a smoke evacuator system can be used as part of surgical procedure to evacuate smoke from a surgical setting.

Growing community of inventors

Duarte, CA, United States of America

Yuman Fong