Chinese Academy of Medical Sciences

Beijing Wehand-bio Pharmaceutical Co., Ltd.

Chinese Academy of Sciences

Guangxi Wehand-bio Pharmaceutical Co., Ltd

Yuling Liu

Xuejun Xia

Zhihua Liu

Wujun Dong

Renyun Wang

Lin Li

Lu Liu

Yun Zhang

Yu Feng

Zhen Chen

Hongliang Wang

Quan Liu

Yue Gao

Jun Ye

Zhihui Song

Sujuan Sun

Jundong Yang

Yiqun Jin

Xiangyang Zhu

Hengfeng Liao

Bangyuan Wang

Junzhuo Zhou

Mingzhi Xie

Yueteng Chen

Zhufang Shen

Dujia Jin

Cuiping Zhou

Yanfang Yang

Zhaodi Fu

Rui Han

Pengxiao Zhang

Ruifang Guo

A plant extraction method includes the following steps: 1) preparation of a crude plant extraction solution; 2) separation of the crude extraction solution through a cation resin and an optional anion resin to obtain a collection solution; 3) concentration of the collection solution obtained in step 2); 4) alcohol precipitation of the concentration solution obtained in step 3); and optionally, step 5) concentration and drying. The method can effectively reduce the content of heavy metals in an extract, and reduce the amount of ethanol used in extraction, thereby improving the product quality and lowering the production cost, and the efficiency and safety of industrial production are improved. The extract obtained by this method can be used to prepare drugs for lowering blood lipid, treating abnormal glucose tolerance, treating diseases related to abnormal blood glucose, or regulating intestinal flora, and can be processed into food products, health-care products or drinks.

Plant extraction method

A flavonoid polyphenol drug self-emulsifying composition based on a flavonoid polyphenol drug-phospholipid complex being used as an intermediate, the composition comprising a flavonoid polyphenol drug-phospholipid complex, an oil phase, an emulsifier and a co-emulsifier, the flavonoid polyphenol drug comprising one or more selected from baicalein, proanthocyanidin, quercetin, curcumin and resveratrol. The described self-emulsifying composition has the beneficial effects of good stability, a high amount of drug loading, high bioavailability, and so on.

Flavonoid polyphenol drug self-emulsifying composition, preparation method therefor, pharmaceutical composition thereof and application thereof

Provided are an insulin-lipid complex, a preparation method thereof, and a formulation thereof. The insulin-lipid complex is prepared by compounding insulin and a lipid material in an organic solvent system containing a low boiling point acid, and drying. The mass ratio of insulin to the lipid material is 1:3&#x2dc;1:20. An oil solution of the insulin-lipid complex and vesicles containing insulin are further provided.

Insulin-lipid complex, preparation method therefor, and preparation thereof

The present invention relates to an effective fraction of alkaloids and the effective fraction is prepared from mulberry twig and its active ingredients are a composition of alkaloids. Determined by HPLC, the percentage of the total alkaloids are 50% or more by weight in the effective fraction and the percentage of the compound 1-deoxynojirimycin is 30% or more by weight in the total alkaloids. The effective fraction of the invention is prepared as the following steps: the mulberry twig is extracted by solvents, and the extract is precipitated by alcohol precipitation or flocculation to remove the impurities, and then concentrated, purified by resin chromatography. The present invention also relates to a pharmaceutical composition containing the said effective fraction of alkaloids and to the use of the effective fraction of alkaloids according to claim-in preparing hypoglycemic agents.

Use of the effective fraction of alkaloids from mulberry twig in preparing hypoglycemic agents

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Beijing, China

Yuling Liu