Hoechst Roussel Pharmaceuticals

Hoechst Marion Roussel

Aventis Pharmaceuticals Inc.

Bristol-myers Company

Sanofi

Other

Hoescht Marion Roussel, Inc.

Aventis Holdings, Inc.

Barbara E. Kurys

Yulin Chiang

Edward J. Glamkowski

Hmr Pharma Inc.

Grover Cleveland Helsley

Joseph Thomas Strupczewski

Kenneth J. Bordeau

Edward J Glamkowski

Joseph T Strupczewski

Gregory M Shutske

Kenneth J Bordeau

Grover C Helsley

Peter A Nemoto

John J Tegeler

David Fink

Dolatrai M Vyas

Terrence W Doyle

Barbara E Kurys

R Richard Hamer

John G Jurcak

Matthias Urmann

David M Fink

Russell R Hamer

Horst Hemmerle

James Hendrix

George Lee

Gregory Shutske

Frank Halley

Gilles Dutruc-Rosset

Adrien Tak Li

Frederick J Ehrgott

Frederic Puech

Jean-Francois Sabuco

William Joseph Hurst

William Arthur Metz, Jr

Brian S Freed

Antonio Almario Garcia

Zhongli Gao

Gilles Doerflinger

Yong Mi Choi-Sledeski

Gregory Bernard Poli

Philippe Burnier

Juan Antonio Gamboa

Jean Merrill

Thaddeus R Nieduzak

Nicola Collar

Richard L Hamer

Sharon Anne Jackson

Thaddeus Nieduzak

Bao-Guo Huang

Frédéric Puech

James P Carey

Sylvain Cote Des Combes

Christophe Pacaud

Paul Angell

Joseph T Tsay

Fernando Camacho

Ann Marie Gelormini

Andrew Giovanni

Joachim E Roehr

Stephen Wayne Harnish

Guyan Liang

Qiuxia Zhao

Sam Rebello

Jospeh T Strupczewski

Jean-Fancois Sabuco

Sylvain Cote-Des-Combes

Juan Anotonio Gamboa

John J Tegler

Sylvain Cote-Des Combes

Adrien-Tak Li

Sam S Rebello

Larry Davis

Jean-François Gilbert

David Marc Fink

Nicola Dawn Collar

James A Hendrix

Jackson Sharon Anne Anne

Kenneth K Bordeau

Joseph T c/o Sanofi-Aventis US Inc Strupczewski

George E Lee

The invention relates to the 6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazine derivatives corresponding to general formula (I): Wherein R, R, R, A, L and B are as defined herein. Also disclosed are the preparative methods and therapeutic use thereof.

6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]-pyridazine and derivatives thereof preparation and therapeutic application thereof

6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazine and derivatives and pharmaceutical compositions comprising the same

The invention relates to heterocyclic substituted carbonyl derivatives that display selective binding to dopamine Dreceptors. In another aspect, the invention relates to a method for treating central nervous system disorders associated with the dopamine Dreceptor activity in a patient in need of such treatment comprising administering to the subject a therapeutically effective amount of said compounds for alleviation of such disorder. The central nervous system disorders that may be treated with these compounds include Psychotic Disorders, Substance Dependence, Substance Abuse, Dyskinetic Disorders (e.g. Parkinson's Disease, Parkinsonism, Neuroleptic-Induced Tardive Dyskinesia, Gilles de la Tourette Syndrome and Huntington's Disease), Dementia, Anxiety Disorders, Sleep Disorders, Circadian Rhythm Disorders and Mood Disorders. The subject invention is also directed towards processes for the preparation of the compounds described herein as well as methods for making and using the compounds as imaging agents for dopamine Dreceptors.

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The present invention comprises methods for the treatment of central nervous system diseases and disorders including mood disorders and sleep disorders through the administration of compounds of formula (I) and formula (II) which are useful as inhibitors of human casein kinase I&#x3b5;. Pharmaceutical compositions comprising compounds of formula (I) or formula (II) as well as methods for their preparation are also disclosed and claimed.

Substituted thienopyrrole carboxylic acid amides, pyrrolothiazole carboxylic acid amides, and related analogs as inhibitors of casein kinase I

The present invention discloses and claims compounds of formula (I) wherein M is N, and K and L are each C with the remaining substituents further defined herein. These compounds are effective as inhibitors of human casein kinase I&#x3b5;, and as such are useful in the treatment of central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) and methods for the preparation of compounds of formula (I) are also disclosed and claimed.

Substituted 1H-pyrrolo[2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase I&#x3b5;

The present invention relates to coumarins of the formula (I): that are useful as inhibitors of nitric oxide synthase. Pharmaceutical compositions and methods of using these compounds as inhibitors of nitric oxide synthase are described herein.

Coumarins as iNOS inhibitors

The present invention discloses and claims compounds of formula (I) as inhibitors of human casein kinase IF, and methods of using said compounds of formula (I) for treating central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) and methods for the preparation of compounds of formula (I) are also disclosed and claimed.

Substituted 1H-pyrrolo[3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase lepsilon

The present invention discloses and claims compounds of formula (I) and formula (II), as inhibitors of human casein kinase I&#x3b5; and methods for using said compounds for treating central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) or formula (II) and a method for the preparation of compounds of formula (I) or formula (II) are also disclosed and claimed.

Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.

Heteroarylpiperidines, and their use as antipsychotics and analgetics

Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amounts of one of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.

Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgesics

Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. Depot derivatives of the compounds are useful for providing long acting effects of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.

Heteroarylpiperidines and their use as antipsychotics

Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents, the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. Depot derivatives of the compounds are useful for providing long acting effects of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.

1-(arylthioalkyl, arylaminoalkyl, or arylmethylenealkyl)-4-(heteroaryl)piperazines and related compounds useful as antipsychotics and analgesics

Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. Depot derivatives of the compounds are useful for providing long acting effects of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.

1-(aryloxyalkyl)-4-(heteroaryl) piperazines and related compounds useful as antipsychotics and analgesics

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Covent Station, NJ, United States of America

Yulin Chiang