Thomas Swan & Co. Limited

Yulia Rogan

David Dunn

Simon Jonathon Grant

Howard Winston Tyrrell Sutton

Lian Hutchings

John Ing Chuan Daly

Sergio Aaron Gamboa Martinez

Craig Anderson

Patrice Georges Antonin Ribiere

Matthew Richard Gibbings

A hydrogenation catalyst, preferably palladium on a support, preferably alumina or activated charcoal support, is used in the presence of lithium salts, with salts such as the borates being preferred. This provides hydrogenation of precursors to give rise to a stereoselective, such as diastereoselective bias in the product of alkene hydrogenation using the catalyst.

Chelate-controlled diastereoselective hydrogenation with heterogeneous catalyst

A catalyst, method of using, and use of a hydrogenation catalyst, preferably palladium on a support, preferably alumina or activated charcoal support. This in the presence of lithium salts, with salts such as the borates being preferred. This provides hydrogenation of precursors to give rise to a stereoselective, such as diastereoselective bias in the product of alkene hydrogenation using the catalyst. This equation, using the preferred substrate, best illustrates the invention: 

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Durham, United Kingdom

Yulia Rogan