Bristol-myers Squibb Compnay

Yuli Wu

Wen-Pin Yang

Steven B Kanner

Han Chang

Gena S Whitney

Juan J Perez-Villar

Xin Huang

Todd G Kirchgessner

Bonnie Hsiang

Yingjie Zhu

Jean S Lynch

Zhaoqing Wang

Juan J Perez-villar

Zhaoging Wang

The current invention discloses nucleic acid and amino acid sequences for novel organic anion transfer proteins ('OATPs'). The invention encompasses the OATPs described herein, together with vectors containing the cDNA sequences, host cells containing the vectors and polypeptides having all or part of an OATP. Also encompasses are uses for OATPs for targeting drugs to specific organs and for modulating the concentration of endogenous substrates.

Organic anion transport proteins

The present invention describes a newly discovered full-length polynucleotide encoding an SH2 domain-containing adapter protein, called human MIST, cloned, isolated and identified from a human spleen cDNA library. Also described are the MIST polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Novel splice variant forms of human MIST are provided. Methods for screening for modulators, particularly inhibitors, of the MIST protein and use of the human MIST polynucleotide and polypeptide for therapeutics and diagnostics are described.

Antibody directed to human mist (mast cell immunoreceptor signal transducer)

The present invention describes a newly discovered full-length polynucleotide encoding an SH2/SH3 domain-containing adapter protein, called hSLAP-2, cloned, isolated and identified. Also described are the hSLAP-2 polypeptide sequence, expression vectors, host cells, agonists, antagonists, anti-sense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Methods for screening for modulators, particularly inhibitors, of the hSLAP-2 protein and use of the hSLAP-2 polynucleotide and polypeptide for therapeutics and diagnostics are described.

Human SLAP-2: a novel SH2/ SH3 domain-containing human SLAP homologue having immune cell-specific expression

Human clnk-related polypeptide, MIST (Mast Cell Immunoreceptor Signal Transducer)

Identification and cloning of a full-length human Clnk-related gene, MIST (mast cell immunoreceptor signal transducer)

Polynucleotides encoding human SLAP-2:a novel SH2/SH3 domain-containing human SLAP homologue having immune cell-specific expression

The current invention discloses nucleic acid and amino acid sequences for novel organic anion transfer proteins (&ldquo;OATPs&rdquo;). The invention encompasses the OATPs described herein, together with vectors containing the cDNA sequences, host cells containing the vectors and polypeptides having all or part of an OATP. Also encompasses are uses for OATPs for targeting drugs to specific organs and for modulating the concentration of endogenous substrates.

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Newtown, PA, United States of America

Yuli Wu