Kyowa Hakko Kogyo Co., Ltd.

Yuko Uosaki

Yutaka Kanda

Mitsunobu Hara

Shun-ichi Ikeda

Takayuki Nakashima

Junji Kanazawa

Yoko Takata

Masami Hamano

Agents for inducing apoptosis comprising a tetrocarcin derivative represented by the following formula (I) or a salt thereof as an active ingredient ( represents a single bond or a double bond; j and k represent 0 or 1; R to R , R to R and R represent a hydrogen atom, a lower alkyl group and the like; R , R , R , R and R to R represent a hydrogen atom, a hydroxyl group, a lower alkyl group and the like; R and R represents a hydrogen atom, a hydroxyl group, a lower alkyl group, a group represented by the following formula (B) (R represents a formyl group and the like, R to R represent a hydrogen atom, a hydroxyl group, a lower alkyl group and the like); R represents a hydroxyl group, a lower alkoxyl group, a lower alkanoyloxy group and the like). The agents are useful as medicaments for preventive and/or therapeutic treatment of diseases resulting from increased expression of Bcl-2 family proteins, for example, cancers, AIDS and the like.

Agent for inducing apoptosis

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Kanagawa, Japan

Yuko Uosaki