Takeda Chemical Industries, Inc.

Takeda Pharmaceutical Company Limited

Yuko Noguchi

Chieko Kitada

Shuji Hinuma

Hideyuki Tanaka

Ryo Fujii

Masaki Hosoya

Kazunori Nishi

Koji Yoshimura

Yugo Habata

Shoji Fukusumi

Kazuhiro Ogi

Masataka Harada

Shoichi Ohkubo

Yasuaki Itoh

Hidetoshi Komatsu

Shinichi Mogi

The present invention relates to novel secretory polypeptides and precursor proteins thereof, which show a high homology to MIA (melanoma inhibitor activity)/CD-RAP (bovine cartilage-derived retinoic acid-sensitive protein); are specifically expressed in the cartilage tissue; and have an effect on the cartilage differentiation. The polypeptides and the DNAs encoding the same can be used for the diagnosis, treatment, or prevention of bone and joint diseases or pathological angiogenesis. As well, the polypeptides are useful as a reagent for screening a compound that promotes or inhibits the activity of the polypeptides. The antibody to the polypeptides can be used for the detection, quantification, or neutralization of the polypeptide in a test sample fluid. Further by using the promoter of the present invention, a therapeutic protein can be expressed predominantly in the cartilage tissue for a gene therapy.

Polypeptide and DNA thereof

Growing community of inventors

Ibaraki, Japan

Yuko Noguchi