Taisho Pharmaceutical Co., Ltd.

Nec Corporation

Yuko Matsunaga

Masakazu Sato

Hideaki Amada

Takaaki Ishii

Hajime Asanuma

Kenji Yamanishi

Tetsuya Yabuuchi

Tetsuo Takayama

Fumiyasu Shiozawa

Noriyuki Miyata

Hironori Katakai

Takeshi Koami

Hiroki Umemiya

Akiko Ikeda

A thiazolylimidazole derivative represented by the formula or a pharmaceutically acceptable salt thereof, and an ALK5 inhibitor, an therapeutic agent for alopecia or a hair growth agent having the above as an active ingredient,wherein:  The present invention provides an inhibitory substance against ALK5 which is a TGF-&#x3b2; type I receptor and provides a hair growth stimulant or a hair growth agent based on its novel activities.

Thiazole derivative

Supplied with a string of vector data as input data, a probabilistic distribution estimation apparatus estimates, by using a stochastic model having hidden variables, a probabilistic distribution in which each data occurs by successively reading the train of vector data. Specifically, the probabilistic distribution estimation apparatus reads values of parameters of the stochastic model having the hidden variables for a value of the input data, calculates, by using the stochastic model, a certainty in which the input data occurs, renews the parameters in response to new read data with past data forgotten, and produce several parameter's values. By using the parameter's values received from the probabilistic distribution estimation apparatus, an abnormality detection unit calculates an information amount of data as an abnormal behavior degree to produce the abnormal behavior degree.

Detection of abnormal behavior using probabilistic distribution estimation

A hydroxyformamidine compound represented by the following formula or a pharmaceutically acceptable salt thereof [wherein Rrepresents a substituted morpholino group, a substituted piperidino group, a piperazin-1-yl group, a substituted piperazin-1-yl group, a thiomorpholin-1-yl group, a perhydroazepin-1-yl group, a perhydroazocin-1-yl group, a tetrahydropyridin-1-yl group, a pyrrolin-1-yl group, etc.; X represents a nitrogen atom or a group represented by CR; and Rto Rare the same or different and each represents a hydrogen atom, a Calkyl group, a Calkoxy group, a trifluoromethyl group or a halogen atom.] There is provided a drug which inhibits an enzyme producing 20-HETE participating in a contracting or dilating action for microvessels and an inducing action for cell proliferation in main organs such as kidney and cerebrovascular vessels.

20-hydroxyeicosatetraenoic acid production inhibitors

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Tokyo, Japan

Yuko Matsunaga