Taisho Pharmaceutical Co., Ltd.

Yuko Hashimoto

Hitomi Takahashi

Hiroyuki Kakinuma

Takahiro Oi

Yohei Kobashi

Hideaki Amada

Yuki Iwata

Takahiro Ol

C-phenyl 1-thioglucitol compounds of the following formula (I) or pharmaceutically acceptable salts thereof or hydrates thereof: [wherein

C-phenyl 1-thioglucitol compound

The present invention provides a 1-thio-D-glucitol compound of the following formula, which shows the action of inhibiting the activity of SGLT2, a pharmaceutically acceptable salt of the compound, or a hydrate of the compound or the salt; and a pharmaceutical comprising such a compound as an active ingredient, especially, a pharmaceutical for preventing or treating diabetes, diabetes-related disease, or diabetic complication. The invention also provides a method for producing the 1-thio-D-glucitol compound and its intermediate. 

1-thio-D-glucitol derivatives

Provided is a novel C-phenyl glycitol compound that may serve as a prophylactic or therapeutic agent for diabetes by inhibiting both SGLT1 activity and SGLT2 activity, thereby exhibiting a glucose absorption suppression action and a urine glucose excretion action. A C-phenyl glycitol compound represented by Formula (I) below or a pharmaceutically acceptable salt thereof or a hydrate thereof  

C-phenyl glycitol compound

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Toshima-ku, Japan

Yuko Hashimoto