Carna Biosciences, Inc.

The Kitasato Institute

Yuko Asamitsu

Masaaki Sawa

Satoshi Omura

Takahiro Miyake

Tokiko Asami

Takayuki Irie

Kazuhiko Otoguro

Masato Iwatsuki

Takao Kiyoi

Yuko Uno

Wataru Kawahata

Aki Ishiyama

Rei Hokari

The present invention provides a novel 2,4,6-substituted pyrimidine derivative, which is a compound represented by formula (I) (in the formula, ring A is a 6-membered heteroaryl group having at least one N atom optionally substituted with R1, R2, and R3; Z is an optionally substituted alkoxy group, an optionally substituted amino group, an optionally substituted heterocycloalkyl group, or an optionally substituted heteroaryl group; and R1, R2, and R3 are each independently selected from the group consisting of a hydrogen atom, a halogen atom, an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted alkoxy group, an optionally substituted cycloalkyloxy group, an optionally substituted heterocycloalkyloxy group, an optionally substituted phenoxy group, an optionally substituted amino group, a nitro group, and a hydroxy group) or a pharmaceutically acceptable salt thereof.

Pyrimidine derivative having antimalarial activity

The purpose of the present invention is to provide a novel triazine derivative of the formula (I): wherein

Triazine derivative

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Kobe, Japan

Yuko Asamitsu