Nippon Shinyaku Company, Ltd.

Yukiteru Sugiyama

Tetsuo Asaki

Jun Segawa

Taisuke Hamamoto

The present invention is directed to an amide derivative having excellent BCR-ABL tyrosine kinase inhibitory activity, or a salt thereof. The present invention provides an amide derivative represented by the following general formula (1): [Chemical 23] (wherein Rrepresents &#x2014;CH&#x2014;R, etc.; Rrepresents alkyl, halogen, haloalkyl, etc.; Rrepresents hydrogen, etc.; Het1 represents a group of the formula [6] as above, etc.; and Het2 represents pyrimidinyl, etc.), or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention is useful as a BCR-ABL tyrosine kinase inhibitor.

Amide derivative and medicine

The present invention provides an amide derivative represented by the following general formula (1): wherein Rrepresents a saturated cyclic amino group, Rrepresents alkyl, halogen or haloalkyl, Rrepresents hydrogen or halogen, Het 2 represents pyridyl or pyrimidinyl, and Het 1 represents a group of the formula [6], or a salt thereof, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention is useful as a BCR-ABL tyrosine kinase inhibitor.

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Kyoto, Japan

Yukiteru Sugiyama