Kyowa Hakko Kogyo Co., Ltd.

Yukiteru Mimura

Masaji Kasai

Shinji Tomioka

Yutaka Osawa

Takehiro Ogasa

Yasushi Shida

Kazumi Amatsu

Yoshiyuki Yamada

Shoichi Mizutaki

Hiroyuki Shinmura

Yasunori Nakaguchi

Kunimi Inoue

Yasuyuki Ono

Makoto Morimoto

Chikara Murakata

Shiro Akinaga

Hiromitsu Saito

Tadashi Ashizawa

Katsushige Gomi

Ikuo Matsukuma

Yoshiaki Masuda

Toru Sugaya

Masahiko Kinugawa

Iwao Chujo

Sachiko Kato

The present invention relates to glutathione monoester sulfonate represented by formula (I): ##STR1## (wherein R.sup.1 represent lower alkyl, and R.sup.2 represents lower alkyl, or substituted or unsubstituted aryl) which readily crystallizes and has high stability, and a simple process for producing the same. According to the process, the product having high purity can be obtained in high yields.

Glutathione monoester sulfonate

Process for producing indolocarbazole derivatives

Disclosed is a process for producing alanylglutamine, which comprises reacting an N-(2-substituted)-propionylglutamine compound represented by the formula (I): ##STR1## where X represents halogen, alkylsulfonyloxy, or substituted or unsubstituted arylsulfonyloxy, with ammonia at a temperature of 60.degree. C. or below. in accordance with the present invention, highly purified alanylglutamine can be produced in a high yield, without racemization.

Process for producing alanylglutamine

Disclosed is a process for producing alanylglutamine, which comprises reacting an N-(2-substituted)-propionylglutamine compound represented by the formula (I): ##STR1## where X represents halogen, alkylsulfonyloxy, or substituted or unsubstituted arylsulfonyloxy, with ammonia at a temperature of 60.degree. C. or below. In accordance with the present invention, highly purified alanylglutamine can be produced in a high yield, without racemization.

Process for producing alanylgutamine

Disclosed is pyrazoloacridone derivatives represented by formula (I): ##STR1## wherein: each of R.sup.1a, R.sup.1b, R.sup.1c and R.sup.1d independently represents hydrogen, lower alkyl, --(CH.sub.2).sub.p --X wherein p represents an integer of 1 to 6, and X represents hydroxy, lower alkoxy or --NR.sup.2a R.sup.2b wherein each of R.sup.2a and R.sup.2b independently represents hydrogen, lower alkyl, or --(CH.sub.2).sub.m --Y wherein m represents an integer of 1 to 6, and Y represents hydroxy, lower alkoxy or --NR.sup.3a R.sup.3b wherein each of R.sup.3a and R.sup.3b independently represents hydrogen or lower alkyl

Pyrazoloacridone derivatives

Novel pyrazoloacridone compounds represented by the following formula: ##STR1## and pharmaceutically acceptable salts thereof have an excellent anti-tumor activity.

6H-pyrazolo-[4,5,1-d,e]acridin-6-one derivatives having anit-tumor

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Shizuoka, Japan

Yukiteru Mimura