Schering Aktiengesellschaft

Yukishige Nishino

Rolf Bohlmann

Martin Schneider

David A Henderson

Helmut Hofmeister

Rosemarie Lichtner

Rudolf Wiechert

Gerhard Sauer

Dieter Bittler

Christa Hegele-Hartung

Peter Strehlke

Karsten Parczyk

Hermann Kunzer

Henry Laurent

Nikolaus Heinrich

Jorg Kroll

Monika Lessl

Klaus Prezewowsky

Karl-Heinrich Fritzemeier

Josef Heindl

Hermann Kuenzer

Ulrich Kerb

Sybille Beier

Friedmund Neumann

Ursula Habenicht

Horst Michna

Hans-Peter Muhn-Seipoldy

Walter Elger

Gunter Neef

Gregor Haffer

Ludwig Zorn

Ulrich Eder

Karl Petzoldt

Hans-Jorg Vidic

Joseph Heindl

Klaus Engel

Christa Hegelehartung

Hermann K&uuml;nzer

Benzocycloheptenes of formula (I), in which R, Rand Y have the meanings that indicated herein, exhibit selective estrogenic activity on bones and are suitable for the production of pharmaceutical agents, especially for prophylaxis and therapy of osteoporosis: 

Benzocycloheptenes, process for their production, pharmaceutical preparations that contain that latter as well as their use for the production of pharmaceutical agents

This invention describes the new benzocycloheptenes of general formula Iin which

Benzocycloheptenes, process for their production, pharmaceutical preparations that contain the latter as well as their use for the production of pharmaceutical agents

11&bgr;-HALOGEN-7&agr;-SUBSTITUTED ESTRATRIENES, PROCESS FOR THE PRODUCTION OF PHARMACEUTICAL PREPARATIONS THAT CONTAIN THESE 11&bgr;-HALOGEN-7&agr;-SUBSTITUTED ESTRATRIENES AS WELL AS THEIR USE FOR THE PRODUCTION OF PHARMACEUTICAL AGENTS

This invention describes the new 7&agr;-(5-methylaminopentyl)-estratrienes of general formula I

7 &agr;-(5-methylaminopentyl)-estratrienes, process for their production, pharmaceutical preparations that contain these 7 &agr;(5-methylaminopentyl)-estratrienes as well as their use for the production of pharmaceutical agents

This invention describes new, substituted 7&agr;-(&egr;-aminoalkyl)-estratrienes of general formula I

7&agr;-(xi-aminoalkyl)-estratrienes, process for their production, pharmaceutical preparations which contain these 7&agr;-(xi-aminoalkyl-estratrienes as well as their use for the production of pharmaceutical agents

This invention describes new, substituted 7.alpha.-(.xi.-aminoalkyl)-estratrienes of general formula I ##STR1## in which side chain SK is a radical of partial formula ##STR2## as well as their physiologically compatible addition salts with organic and inorganic acids. The new compounds represent compounds with very strong antiestrogenic action. The compounds according to the invention are, on the one hand, pure antiestrogens, or, on the other hand, antiestrogens with estrogenic partial action. Based on this spectrum of action, the new compounds are highly suitable for the production of pharmaceutical agents for tumor therapy and hormone replacement treatment.

7.alpha.-(.xi.-aminoalkyl)-estratrienes, process for their production,

This invention describes the new triphenylethylenes of general formula I ##STR1## in which n means an integer from 1 to 10,

Triphenylethylenes, process for their production, pharmaceutical

Dihydrospirorenone, ##STR1## preferably together with an estrogen, can be used for the production of a pharmaceutical agent suitable for treatment of hormonal irregularities during premenopause (menstruation stabilization), for hormonal substitution therapy during menopause, for treatment of androgen-induced disorders and/or for contraception.

Dihydrospirorenone as an antiandrogen

11.beta.-substituted 14,17-ethanoestratrienes, process for their

The disclosure relates to cycloalkylene azoles of general Formula I ##STR1## wherein ##STR2## is a carbocyclic or carbopolycyclic group optionally carrying at least on a alkyl substituent,

Cycloalkylene azoles, and their use as aromatase inhibitors

[3,2-c]Pyrazole and [3,2-d]triazole steroids are useful anti-androgens.

Antiandrogenic [3,2-c]pyrazole and [3,2-d]triazole steroids

Pharmaceutical preparations comprising functionalized vinyl azoles of formula I ##STR1## wherein the substituents are as defined herein, including novel compounds, as well as methods of use and methods of their preparation, are provided.

Functionalized vinyl azoles and methods of use

The disclosure relates to cycloalkylene azoles of general Formula I ##STR1## wherein ##STR2## is a carbocyclic or carbopolycyclic group optionally carrying at least one alkyl substituent,

Cycloalkylene azoles and their use as aromatase inhibitors

Growing community of inventors

Berlin, Germany

Yukishige Nishino