Hamamatsu-photonics K.k.

University of Tsukuba

Hamamatsu University School of Medicine

National University Corporation Hamamatsu University School of Medicine

Yukio Ueda

Yutaka Yamashita

Kenji Yoshimoto

Daisuke Yamashita

Etsuko Yamaki

Hiroyuki Ogura

Hatsuko Nasu

Etsuko Ohmae

Harumi Sakahara

Yutaka Tsuchiya

Toshihiko Suzuki

Hiroyuki Kudo

Kazuyoshi Ohta

Hiroko Wada

Naoya Saito

Mitsuharu Miwa

Katsuhiko Sato

Shigeru Sakamoto

Yoshinori Tamaoki

Hideo Takahashi

Keiji Suyama

Toshihiko Mizuno

Toshiyuki Tanaka

Koji Yamanaka

Nobuko Yoshizawa

Nobuhiro Morita

Seiichiro Hashimoto

The present invention relates to the phantom comprises water, an oil, an emulsifier and an oil coagulating agent.

Phantom, method for producing same, and kit for making phantom

The present invention relates to the phantom comprises water, an oil, an emulsifier and a water coagulating agent, and having a scattering coefficient of 5 to 20 cmat a wavelength of 750 to 1000 nm.

Phantom and method for producing same

A phantom design method includes a correction step and a calculation step. In the correction step, an absorption spectrum of a target of spectroscopic measurement by a near infrared spectrometer is corrected based on a refractive index of the target and a refractive index of a resin used as a base material of a phantom to generate a corrected absorption spectrum. In the calculation step, based on an absorption spectrum of the resin and an absorption spectrum of each of N types of dyes, a concentration of each of the N types of dyes to be contained in the base material is calculated such that an absorption spectrum of the phantom constituted by the base material containing the N types of dyes approximates the corrected absorption spectrum in a predetermined wavelength range of a near infrared region.

Simulation sample design method, simulation sample manufacturing method, simulation sample design device, program, and recording medium

A device for radiating pulsed light toward a thrombus in a blood vessel includes a light source configured to output monitoring light to be radiated into the blood vessel, a light detector configured to detect returned light of the monitoring light and output a detection signal, and a computer configured to acquire a time waveform, which is a change in an intensity of the returned light over time, based on the detection signal, wherein the computer is configured to obtain a parameter on the basis of the time waveform and evaluates a reaction in the blood vessel according to the radiation of the pulsed light on the basis of the parameter.

Monitoring device and method of operating the same

A breast measurement apparatus includes a distance measurement unit measuring a distance from a skin to a light absorption portion for a measurement region of a breast which is a normal region including no tumor or an object region including a tumor, a light measurement unit measuring a hemoglobin amount in the measurement region by a light measurement method using measurement light of a predetermined wavelength, a correlation data storage unit storing normal correlation data of the distance to the light absorption portion and a normal hemoglobin amount generated based on measurement results for normal regions, and an evaluation value calculation unit calculating a property evaluation value of the tumor based on the normal hemoglobin amount, obtained from the normal correlation data and the distance to the light absorption portion in the object region, and an object hemoglobin amount in the object region.

Breast measurement method and measurement device

A mammography device is disclosed. The mammography device includes a container configured to surround the breast and a plurality of optical fibers attached to be directed inward in the container and configured to perform radiation and detection of light. The container has a base member having an opening, a plurality of annular members continuously disposed to come in communication with the opening, and a bottom member disposed inside the annular member spaced the farthest distance from the base member. The annular members and the bottom member are configured to relatively displace the adjacent annular member on the side of the base member or the base member in a communication direction. Some of the plurality of optical fibers is attached to the plurality of annular members.

Mammography device

A breast measurement apparatus comprises a receptacle for surrounding a breast; a plurality of optical fibers for irradiating the breast with examination light and detecting transmitted scattered light from the breast; an inner image generation unit for generating an optical CT image concerning the breast according to a detection signal of the transmitted scattered light; an ultrasonic probe, arranged so as to face the inside of the receptacle, for scanning the breast with an ultrasonic wave and receiving a reflected wave from the breast; an image generation unit for generating an ultrasonic image concerning the breast according to the reflected wave; and a mechanism for injecting and discharging a liquid interface agent into and from the inside of the receptacle.

Breast measurement apparatus

In measurement data selection, when a vector composed of measurement data obtained for respective combinations of light emitting positions, light detection positions, and resolving times in a time-resolved waveform is given as y, a vector in which pixel values of learning image data are components is given as x, and a system matrix for calculating internal image data from the measurement data is given as A, the vector y which meets the conditional expressions (2) and (3)min&#x2225;&#x2003;&#x2003;(2),&#x2225;&#x2266;&#x3b5;&#x2003;&#x2003;(3)or the conditional expression (4)min(&#x2225;)&#x2003;&#x2003;(4)is determined, and upon measurement of a subject, only the measurement data corresponding to nonzero components of the vector y is used to prepare the internal image data.

Measurement data selection method for biometric device, light exit position determination method for biometric device, and biometric device

The bioinstrumentation apparatus includes a light irradiation unit irradiating a measurement region with light, a light detection unit detecting diffused light from the measurement region, and a computing unit generating a reconstructed image for the interior of the measurement region. The computing unit calculates J coefficients wset for every pixel of the reconstructed image and more than 0 and not more than 1 (where J is the number of pixels of the reconstructed image) and carries out successive approximation computation by the following iterative formula(where k is an integer from 1 to N, N is the number of times of iterative computation, xis a pixel value of the jth pixel on the kth iterative computation, and dis an update amount of the jth pixel on the kth iterative computation) to generate the reconstructed image.

Biometric apparatus and image-generating method

A bioinstrumentation apparatus irradiates light onto a measured region of a subject, detects diffused light to acquire internal information on the measured region, and includes: a container holding a light transmitting medium; a light irradiation unit including a plurality of light emitting ends fixed to the container and irradiating a first light and a second light that mutually differ in wavelength onto the measured region that is immersed in the medium; a light detection unit including a plurality of light detecting ends fixed to the container and detecting the diffused light from the measured region; and a computing unit computing the internal information based on an output signal from the light detection unit; the wavelength of the first light being a wavelength at which an absorption coefficient of the measured region and a mean value of absorption coefficient of the medium are substantially equal, the wavelength of the second light being a wavelength at which the absorption coefficient of the measured region is greater than the mean value of the absorption coefficient of the medium, and the computing unit computing the internal information based on an output signal related to diffused light of the first light and computing boundary information between the measured region and the medium based on an output signal related to diffused light of the second light.

Bioinstrumentation apparatus

The present device is equipped with a measurement site holder that is constructed using a negative impression of the measurement site . As a result, variation in the measured values caused by the non-uniform distribution of components in the measurement site is reduced, so that variation in the measured values caused by variations in the light path length accompanying variations in the shape of the measurement site , and by variations in blood flow or the like that accompany differences in the contact pressure, can be reduced. Since living-body information and measurement parameters for the patient are recorded on a recording medium mounted on a measurement site holder for the exclusive use of the individual patient, the erroneous acquisition of living-body information for individual patients can be prevented, and reproducible measurements can be performed.

Noninvasion biological optical measuring instrument, measured portion holding device, and method for manufacturing the same

An optical CT apparatus is mainly composed of a container filled with an optical interface member ; a light-projecting section, comprising a light source and an optical switch , for projecting light into the container ; a light-detecting section, comprising photodetectors and shutters , for detecting the light from the inside of the container ; and an arithmetic/control section for calculating a spatial distribution of absorption coefficient. The arithmetic/control section has a function of determining a spatial distribution of a characteristic amount concerning a part of an object to be measured according to a comparison of an optical intensity signal actually measured by each detector in a state where the container is filled with the optical interface member with an optical signal actually measured by each detector in a state where the optical interface member is partly replaced by the part of object to be measured

Optical CT apparatus and image reconstructing method

A method for measuring an internal property distribution which includes making measurement light incident from a plurality of light incidence positions on a surface of a measured object, detecting the measurement light that has passed through the object, successively or simultaneously, at at least one light detection position out of a plurality of light detection positions on the surface of the object. A plurality of measurement values obtained by a plurality of combinations of the light incidence position and said light detection position are extracted. A mean value of the measured values are calculated to obtain a reference value and a change amount of a predetermined internal property in each of the plurality of regions of the object are calculated using the plurality of measured values obtained. The reference value thereby establishing an internal property change amount distribution in the object.

Method and apparatus for measuring internal property distribution

An arithmetic control mechanism of the present optical CT apparatus calculates first light densities in output portions of an object on the basis of a numerical analysis method, when it is assumed that the object is divided into fine segments and all segments have the same value as an absorption coefficient under predetermined conditions equivalent to an actual measurements; and calculates second light densities in the output portions on the basis of the method, when it is assumed that sequentially selected one of the segments has a specific value as an absorption coefficient under the predetermined conditions. Further, the mechanism calculates, as influences of the segments, ratios of the first to the second light densities, thereby obtaining an influence matrix corresponding to an arrangement of the segments; calculates relative ratios of the third light densities in the output portions on the basis of the actual measurements to the fitst light densities, thereby obtaining a relative ratio matrix corresponding to arrangements of input and output portions of the object; and performs a matrix calculation by using the influence matrix and the relative ratio matrix, thereby obtaining feature data of the segments for reconstructing a tomographic image of the object.

Optical computer tomographic apparatus and image reconstruction method

Measuring scattering and absorption properties of a scattering medium according to the following: (a) causing pulsed measuring light having a predetermined wavelength to enter the scattering medium; (b) performing time-resolved measurement of the measuring light having diffusively propagated in the scattering medium at light detection positions corresponding to a plurality of combinations, each comprising a light incidence position on the scattering medium in the first step and a light detection position on the scattering medium where the measuring light entered the scattering medium in the first step and a light detection position on the scattering medium where the measuring light is detected, having different incidence-detection distances between the light incidence position and the light detection position; (c) calculating a plurality of mean optical pathlengths of the measuring light corresponding to the plurality of incidence-detection distances, based on results of the time-resolved measurement measured in the second step; and (d) calculating a scattering coefficient and an absorption coefficient in the scattering medium, based on a plurality of simultaneous relations consisting of calculation values of the plurality of mean optical pathlengths corresponding to the incidence-detection distances, calculated in the third step, and a theoretical equation of the mean optical pathlengths derived in correspondence to light diffusion properties comprising a scattering property and an absorption property in diffusive propagation paths in the scattering medium.

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Hamamatsu, Japan

Yukio Ueda