Mitsui Toatsu Chemicals, Incorporated

Mitsui Chemicals, Inc.

Mochida Pharmaceutical Co., Ltd.

Yukio Shimazaki

Ryo Tanaka

Hisahiro Ishiwari

Kiyoshi Sakai

Yasuhito Tanaka

Tamotsu Fukuda

Yasuyuki Kuroiwa

Shiro Takagi

Masahiko Ishibashi

Miyuki Kawashima

Nobuhiro Kawashima

Miki Suzuki

Aqueous protein-containing solutions, in which a protein is dissolved at a high concentration at a pH near the isoelectric point of the protein by adding an anionic polymer or a salt thereof to the solution. Pharmaceutical formulations using a physiologically active protein are prepared using this technique.

Aqueous solution of t-PA

A thrombolytic composition containing tissue type plasminogen activator or a derivative thereof in combination with an anionic polymer or a salt thereof and an amine compound or a salt thereof or in combination with an anionic polymer or a salt thereof, an amine compound and an acid or a salt thereof. The composition is an aqueous solution or a lyophilized preparation which can be stably dissolved on dilution at near neutral pH in both pharmaceutical solutions having high salt concentrations, such as physiological saline, and pharmaceutical solutions having low salt concentrations, such as a 5% glucose solution. Clinically useful products for infusion or injection are prepared to be used at a pH near neutral.

Method of improving solubility of tissue plasminogen activator

A freeze-dried monoclonal antibody preparation is prepared by adding to a solution of the monoclonal antibody gelatin or carboxylic acid or its salt, to prevent denaturation of the monoclonal antibodies during freeze-drying. Freeze-dried monoclonal antibody preparations having stablized antigen-binding activity result and may be used as an adminiculum for immunoauxotherapy for prophylaxis and treatment of bacterial infectious diseases and viral infectious diseases.

Freeze-dried preparation containing monoclonal antibody

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Mobara, Japan

Yukio Shimazaki