Shimadzu Corporation

Yukio Oikawa

Shigeyoshi Horiike

Masaki Kanai

Maiko Nakaya

Tetsuo Ohashi

Katsumasa Sakamoto

Takahiro Nishimoto

Hiroshi Tanaka

Kei Shinada

Jun Yanagibayashi

Hiroaki Nakanishi

Hirotaka Koyama

A concentrator includes a casing, a separation membrane that sections an inner space of the casing to form a flow path in the casing, a first supplier that supplies a first liquid from a first position of the casing to the flow path such that the first liquid flows along the separation membrane in a first direction, a second supplier that supplies a second liquid from a second position of the casing to the flow path such that the second liquid flows along the separation membrane in a second direction opposite to the first direction, and a third supplier that supplies a third liquid including a target component having a size that does not allow permeation of the target component through the separation membrane from a third position of the casing to the flow path.

Concentrator, analysis system including same and concentrating method

The suppressor system is provided with: a suppressor which has an eluent flow path and a suppression solution flow path, the eluent flow path and the suppression solution flow path being separated from each other by an ion exchange membrane; a circulation flow path which connects the inlet and the outlet of the suppression solution flow path of the suppressor, and circulates a suppression solution; an ion exchange resin column which is provided on the circulation flow path, and is equipped with a resin accommodation unit through which the suppression solution flowing out of the suppressor is passed, an acidic or alkaline ion exchange resin being accommodated in the resin accommodation unit; and a life detector which determines the life of the ion exchange resin in the ion exchange resin column.

Suppressor system, and method for determining life of ion exchange resin column

A field-flow fractionation device includes a separation channel, a carrier fluid supplier, a separation membrane, a waste liquid chamber, a cross-flow flow rate adjuster, and a carrier fluid adder. The carrier fluid adder is configured to add, to a flow of a carrier fluid having passed through the separation membrane, a flow of another carrier fluid at a carrier fluid adding position set on an upstream side of the cross-flow flow rate adjuster so that the flow rate of the carrier fluid flowing into the cross-flow flow rate adjuster is larger than the flow rate of the carrier fluid having passed through the separation membrane.

Field flow fractionation device

Field flow fractionation device includes a channel switching unit for switching the connection of a second carrier fluid supply unit to any one of the second inlet port of an upper separation cell, the first inlet port of a lower separation cell, or the second inlet port of a lower separation cell. Furthermore, the second carrier fluid supply unit is connected to the second inlet port of an upper separation cell during the process of focusing to generate flow of carrier fluid counter to the flow of carrier fluid from the first inlet port within the upper separation cell, whereas the second carrier fluid supply unit is connected to the first inlet port or the second inlet port of a lower separation cell after conclusion of focusing in the upper separation cell.

Provided is a field-flow-fractionation apparatus that is configured to supply a carrier fluid to a waste fluid chamber through a fluid supply flow path at a flow rate higher than a set flow rate of a flow rate adjusting part at a timing between an end of analysis of a sample and a start of analysis of a subsequent sample, thereby forming a flow of the carrier fluid from the waste fluid chamber to the separation channel. Accordingly, the sample adhering to a separation membrane is separated from the separation membrane and is discharged from the outlet port.

Cleaning method of field-flow-fractionation apparatus

A flow-type field-flow fractionation apparatusincludes a first heaterand a second heater. The first heaterheats a carrier fluid between a first pumpand a separation cell. The second heaterheats a focus fluid between a second pumpand the separation cell. Thus, the carrier fluid heated by the first heateris sent by the first pumpand flows into the separation cell, and the focus fluid heated by the second heateris sent by the second pumpand flows into the separation cell. This can stabilize temperatures of the carrier fluid and the focus fluid flowing into the separation cell. Then, when an analysis is performed using the flow-type field-flow fractionation apparatus, the analysis can be performed with high reproducibility.

Flow-type field-flow fractionation apparatus

A field flow fractionation apparatus includes a separation channel provided with an inlet port and an outlet port at both ends and forming a space through which a carrier fluid flows between the inlet port and the outlet port, a separation membrane which is a wall surface that defines the separation channel and is parallel to a channel flow in which a carrier fluid flows in the separation channel from the inlet port toward the outlet port, and has a property of permeating the carrier fluid and not permeating particles to be separated, and a discharge port that discharges the carrier fluid having permeated through the separation membrane to outside. At least a part of the surface of the separation membrane is an ion exchangeable region in which a functional group having ion exchangeability is modified.

Field flow fractionation apparatus

The present invention provides a method for hydrophobization of a hydrophilic material, the method including introducing a hydrophobic group into a hydroxyl group (&#x2014;OH group) on a surface of the hydrophilic material. A method for hydrophobization of a hydrophilic material, the method comprising reacting a hydrophilic material to be hydrophobized with a hydrophobic group-containing silylating agent in presence of an amino acid as a reaction accelerator, to introduce a hydrophobic group-containing silyl group to a surface of the hydrophilic material. A hydrophobized silica gel column filler is produced by using the method. Further, a hydrophobized silica gel column is produced by filling a column with the hydrophobized silica gel column filler.

Method for hydrophobization of hydrophilic material

Provided is a method for separating a substance accommodated in a vessel-shaped structure comprising subjecting a vessel-shaped structure, which includes a vessel portion a, a vessel portion b, and a self-fusing material X connecting the both vessel portions, and which accommodates a substance selected from the group consisting of a liquid, a solid a gas, and a dispersion system, to the steps: (i) pulling the vessel portion a and the vessel, portion b away from each other to extend the self-fusing material X; (ii) fusing the extended self-fusing material X together between the vessel portion a and the vessel portion b to separate the accommodated substance; and (iii) cutting a fused part of the self-fusing material X to separate the vessel-shaped structureinto a separated structure.

Method for separating substance accommodated in vessel

A magnetic particle manipulation method for magnetic particle comprises the steps of; subjecting magnetic particles and a magnetic solid having a larger particle diameter than said magnetic particles to existing together in a liquid layer, and moving said magnetic solid and said magnetic particles in said liquid layer by a magnetic field manipulation. According to one aspect of the present invention; a manipulation method for magnetic particles comprising the steps of; moving magnetic particles in a first liquid layer into a gelled medium layer by a magnetic field manipulation in a device, wherein gelled medium layers and liquid layers are in-place alternately in a container, moving said magnetic particles present in the gelled medium into a second liquid layer by the magnetic field manipulation; and moving said magnetic particles along with said magnetic solid in the second liquid layer.

Method for manipulating magnetic particles and device for manipulating magnetic particles

An ion processing device includes, on the side of an anion exchange layer of a bipolar membrane which is formed by stacking an anion exchange layer and a cation exchange layer, an anion-side channel which is filled with an anion exchanger, and an anion removal channel provided via an anion exchange membrane, and also includes an anode for moving anions from the anion-side channel to the anion removal channel through the anion exchange membrane. Further, a cation-side channel which is filled with a cation exchanger and a cation removal channel provided via a cation exchange membrane are included on the side of the cation exchange layer of the bipolar membrane as well as a cathode for moving cations from the cation-side channel to the cation removal channel through the cation exchange membrane.

Ion processing device, ion chromatograph provided with the ion processing device, and eluent generator provided with the ion processing device

A suppressor is structured by an ion exchange section being structured by an eluate path forming member forming an eluate path and a regenerant path forming member forming a regenerant path being stacked across an ion exchange film, and a heat-conductive heat block covering the outside of the ion exchange section. A separation column, the suppressor, and an electrical conductivity meter are accommodated in a common constant temperature bath. The inside of the constant temperature bath is feedback-controlled by a temperature control section so as to be maintained at constant temperature.

Ion chromatograph

[Problems] To immobilize a chain-type biopolymer in an elongated state at a predetermined position on a substrate. [Means for Solving Problems] A substrate () for immobilizing a biopolymer, which has a mask layer () provided with multiple through-holes at predetermined positions on a flat active face, is brought into contact with a solution containing a chain-type biopolymer (). After thus immobilizing the nucleic acid molecule () on the active face within a through-hole () via physical adsorption or chemical binding, the mask layer () is dissolved in a solvent and thus removed while leaving the nucleic acid molecule () alone having been immobilized on the active face within the through-hole (). Subsequently, the nucleic acid molecule () having been immobilized on the active face is elongated.

Substrate for immobilizing biopolymer and method of immobilizing biopolymer by using the same

Disclosed herein is a suppressor using one ion-exchange tube which has an inner diameter close to that of a tube connected to a separation column and which is constituted by an ion-exchange membrane. The ion-exchange tube is folded or wound more than once in a plane into a sheet form to provide an ion-exchange tube sheet through which an eluate from a separation column flows. The ion-exchange tube sheet is accommodated in a container. The container provides a regenerant flow channel so that a regenerant is allowed to flow on both sides of the ion-exchange tube sheet.

Growing community of inventors

Kyoto, Japan

Yukio Oikawa