Eisai Company, Limited

Yukio Narabe

Shizumasa Kijima

Kimio Hamamura

Yoshio Urawa

Yoshihiko Hisatake

Takashi Banba

Kichisaburo Hamamura

Yoshihiro Hisatake

Yutaka Ohnuki

A terpene derivative represented by the general formula (I): ##STR1## wherein R.sup.1 represents a lower alkyl group; R.sup.2 represents an alkyl group, a cycloalkyl group, a cycloalkylalkyl group, an aryl group, an arylalkyl group or a heteroaryl group; n is 0 or 1 or 2; and the symbol '  ' represents a single or double bond with the proviso that both of the linkages adjacent to each other are not simultaneously single bonds or double bonds which are useful for the preparation of drug, food, perfume and so on, and a process for preparing thereof.

Terpene derivatives and process for preparing the same

A terpene compound having the formula (III) is produced by reacting an allylic halide having the formula (I) with a Grignard reagent having the formula (II) in the presence of anhydrous zinc chloride and a copper compound or an organic zinc halide compound having the formula (IV) in the presence of a copper compound, provided that when A-A is C-C, R' is hydrogen and when A-A is C=C, X is chlorine. ##STR1##

Process for the preparation of terpenes

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Ibaraki, Japan

Yukio Narabe