University of Tsukuba

Japan Science and Technology Agency

Nanocarrier Co., Ltd.

Other

Jsr Corporation

Johnson and Johnson Vision Care, Inc.

Japan Science and Technology Corporation

Nof Corporation

Research Development Corporation of Japan

Toudai Tlo, Ltd.

Transparent Inc.

Nissan Chemical Industries Limited

Mitsubishi Kagaku Iatron, Inc.

K. K. Vayu

General Incorporated Association Tsukuba Global Innovation Promotion Agency

Yukio Nagasaki

Kazunori Kataoka

Masao Kato

Hidenori Otsuka

Teruo Okano

Tadahito Takahashi

Toru Yoshitomi

Michihiro Iijima

Yutaka Ikeda

Takehiko Ishii

Yasuhisa Sakurai

Miki Kato

Hiroshi Kobayashi

Yasuhiro Horiike

Masayuki Yokoyama

Naoya Shibata

Atsuhiko Ogura

Kazunori Emoto

Teruo Nakamura

Masami Nakamae

Binh Long Vong

Fumiko Aboshi

Tomoko Jomura

Tsutomu Takezawa

Yoshinori Katsuyama

Nobuyuki Ohsako

Aki Hirayama

Atsushi Ueda

Atsushi Harada

Hitoshi Furusho

Eui-chul Kang

Nobuhiro Hoshino

Yoshinobu Baba

Mari Tabuchi

Teiji Tsuruta

Yoshitsugu Akiyama

Akira Matsumura

Hisae Miyamoto

Katsumi Chikama

Mitsuhiro Kaneko

Hiroaki Sakamoto

Teppei Uno

Hisato Hayashi

Shiro Ishii

Katsumi Uchida

Yasuo Sato

Yuji Hiramatsu

Daisuke Wakebayashi

Takahisa Hayashida

Ken Suzuki

Hotaka Ito

Takahito Kutsuna

Carmen Scholz

Shinpei Kudo

Kouya Akasaka

Takuya Inagaki

Chie Kuwahara

Min Ley Pua

Pennapa Chonpathompikunlert

Hikaru Hisano

Tatsuya Yaguchi

Mayo Yamashita

Md Amran Hossain

Tomoki Yoshinari

Hiromichi Kawasaki

Jinya Katamachi

Hirofumi Matsui

Takashi Mamiya

Kensuke Suzuki

Hideo Tsurushima

Aiki Marushima

Kazuko Toh

Daisuke Miyamoto

Junya Kaneko

Hiroyuki Nakagawa

Quoc Thang Bui

Shigeki Sasaki

Fumi Nagatsugi

Motoi Oishi

Yasuko Tanaka

Ryosuke Kodaka

A copolymer which includes hydrophilic and hydrophobic blocks, which can form nanoparticles in which a physiologically active substance can be efficiently packaged therein and which are stable under acidic conditions. The hydrophilic segment of the copolymer is composed of polyethylene glycol (PEG) and the hydrophobic segment is composed of polystyrene. The hydrophobic segment has a side chain, and the side chain has ends to which a cyclic nitroxide radical having a radical scavenging function and a trialkoxysilane are covalently bonded.

Copolymer containing cyclic nitroxide radical and trialkoxysilyl in side chain, and use thereof

Provided is a coating agent which can be stably immobilized on metal surface, and which can give blood compatibility. Provided is a copolymer which is usable as the above-mentioned coating agent that comprises PEG segment and a segment which has a phosphoric acid residue (PO(&#x2014;OH)) and a cyclic nitroxideradical randomly as a side chain or a pendant group.

Nitroxylradical-containing copolymer which has phosphoric acid residue, and the use of the same

A method for efficiently producing a poly(ethylene glycol)-b-poly(halomethylstyrene), a novel poly(ethylene glycol)-b-poly(halomethylstyrene) produced using the method, and a derivative thereof. The target novel copolymer can be provided by introducing a functional group, which enables reversible addition-fragmentation chain transfer (RAFT) polymerization, to the &#x3c9; terminal of poly(ethylene glycol) and copolymerizing the resulting poly(ethylene glycol) with a halomethylstyrene.

Poly(ethylene glycol)-b-poly(halomethylstyrene), derivative thereof, and method for producing same

An object of the present invention is to provide a composition that serves as an efficient arginine substrate for inducible NO synthase (iNOS) in tumor. The present invention provides a polyion complex (PIC) of PEG-b-poly(L-Arg) or poly(L-Arg)-b-PEG-b-poly(L-Arg) and a polyanionic polymer, and use thereof.

Polyion complex of poly(L-arginine) segment-containing block copolymer and polyanionic polymer

[Problem] To provide a composition capable of effectively preventing adhesion. [Solution] An adhesion-preventing preparation comprising, as an active ingredient, a composition comprising an A-B-A triblock copolymer, in which A denotes a cationically chargeable polymer block and B denotes a water-soluble block that comprises a poly(ethylene glycol) (or poly(oxyethylene)) chain, and a polyanionic polymer.

Adhesion-preventing preparation comprising composition comprising polycationic triblock copolymer and polyanionic polymer

[Problem] To provide a physiologically active peptide-loaded stable composition for injection into living bodies. [Solution] A composition containing a triblock copolymer represented by formula (I), a polyanionic polymer and a physiologically active peptide:CNR-PEG-CNR&#x2003;&#x2003;(I)

Composition containing polycationic triblock copolymer, polyanionic polymer and physiologically active peptide

A substrate surface on which either a substance to detect analyte or an analyte per se is immobilized, which surface is formed by a treatment of substrate surface with a liquid which contains uncrosslinked polymer based on polyethylene glycol chain segment, said treatment conducted either simultaneously with the immobilization of said substance or analyte or after said substance or analyte has been immobilized on said surface. The non-specific adsorption of impurity protein or the like which is co-existent in sample for assay is significantly restrained.

Surface of substrate onto which non-specific adsorption is restrained

Provided is a triblock copolymer represented by General Formula (I):CNR-PEG-CNR&#x2003;&#x2003;(1)or a polycation thereof, wherein

Triblock copolymer and use therefor

Provided is a prodrug of 2-nitro-1-imidazolepropionic acid and a therapeutically active organic compound having on the molecule an amino group, a cyclic amino group or a hydroxyl group, particularly a prodrug in which the therapeutically active organic compound is selected from among antitumor agents. The prodrug cleaves specifically under hypoxic conditions in vivo to exhibit the inherent therapeutic activity.

Prodrug using nitroimidazole

Provided is an organic-inorganic hybrid composite of a polymerized cyclic nitroxide radical compound and inorganic nanoparticles. Such a composite is capable, for example, of maintaining a stable nanoparticle shape in gastric fluid, and can be used by itself or as a carrier for delivery of another drug to the intestines.

Organic-inorganic hybrid composite of polymerized nitroxide compound and inorganic particles

The present invention allows formation of covalent bonds in a bioactive compound having at least one amino group so as to efficiently provide the compound modified with PEG. The present invention thus provides a functionalized polyethylene glycol having a structure that allows reaction of two aldehyde groups with one amino group to form two covalent bonds.

Branched polyethylene glycol and use thereof

A method of covalently bonding a cyclic nitroxide radical compound to a hydrophobic block of a specific hydrophylic-phobic block copolymer, and polymerized cyclic nitroxide radical compound copolymerized in this manner, as well as use of such a compound, for instance, in the medical field are provided. The compound demonstrates long term stability in vivo under reductive environment.

Polymerized cyclic nitroxide radical compound and use thereof

Surface of base material being inhibited in non-specific adsorption

This invention provides a method to detect analyte which comprises preparing fine particles which have a chargeable group in their core and a hydrophilic polymer chain in their shell; obtaining an agglutinated matter by forming a biologically specific bond between a specific residue on the surface of fine particles and analyte, and by simultaneously forming a bond by the electrostatic interaction between impure protein and said particles; and subsequently cleaving only the latter bond by raising ionic intensity. Thus, this invention provides a method to detect analyte with rapidity and high sensitivity with use of agglutination reaction.

Method of high-speed detection for biological analyte

Parenchymal cells are cultivated on cultivated endothelial cells or cultivated fibroblasts which have been separated by a surface of a specific hydrophilic polymer, and which have been patterned. A culture which contains thus formed patterned spheroids of cultivated parenchymal cells is thereby provided by this invention. This culture maintains a function which is specific to the parenchymal cells over a long period of time.

Cultured cell construct which contains spheroids of cultured animal cells and the use thereof

Growing community of inventors

Moriya, Japan

Yukio Nagasaki