Kaken Pharmaceutical Company, Ltd.

Kaken Chemical Co., Ltd.

Yukio Miyazaki

Hideo Sugawara

Machiko Sugiyama

Katsuhiro Nakamura

Masahide Nomura

Ryusuke Taguchi

Akio Seino

Akira Shibata

Yasuhiko Hamazaki

Akiya Furuichi

Goro Yabuta

Hideo Saito

Taku Mizuno

Noboru Otake

Kiyoshi Tsuda

Yuko Nakamura

Masayuki Hara

Nobuko Takahashi

Haruyasu Kinashi

Tateo Yahagi

Kaoru Hara

Tomonori Takashina

Singo Yoneda

Hiroko Kasahara

Substance F-0368 of the formula: ##STR1## or salts thereof is prepared by culturing Kitasatosporia sp. F-0368 in a culture medium thereby producing substance F-0368, and then isolating and collecting substance F-0368 from the culture medium.

Novel substance for agricultural use

Disclosed in the present invention are: a substance F-0368 or salts thereof having the following structural formula ##STR1## a method for production of the substance F-0368 or salts thereof, wherein an F-0368-substance-producing-microorganism belonging to a genus Kitasatosporia is cultured, and the substance F-0368 is isolated and collected from the cultured substance; a method for production of the substance F-0368 or salts thereof, wherein 3-methyl-4-lower alkoxy carbonyl-2(5H)-furanone represented by the following general formula is subjected to hydrolytic reaction ##STR2## (where: R represents a straight or branched lower alkyl group having 1 to 6 carbon atoms); a composition which consists essentially of the substance F-0368 or salt thereof, a diluent permissible in the agricultural chemicals, and a carrier or an excipient; a preventive agent for plant diseases such as rice blast disease and bacterial leaf blight disease, which consists essentially of an effective amount of the substance F-0368 or salts thereof as the active component, a diluent permissible in the agricultural chemicals, and a carrier or an excipient; a method for preventing plant diseases, wherein plants are treated with the preventive agent; a disinfectant for agricultural use to prevent plant disease such as rice blast disease and bacterial leaf blight disease, which consists essentially of an effective amount of the substance F-0368 or salts thereof, as the active component, a diluent permissible in the agricultural chemicals, and a carrier or an excipient; materials for agricultural use containing therein the substance F-0368 or salts thereof; a method for growing plants, wherein the plants are cultivated by use of the agricultural materials; and an F-0368-substance-producing microorganism (Kitasatosporia sp. F-0368; FERM BP-2259).

Lactone compound of agricultural utility

An antibiotic F-0769 having the following properties:

Antibiotic F-0769, process for its production, and its use as a growth

Antibiotic Actinomadura-L-31 A has the characteristics as the hydrochloride salt:

Antibiotic Actinomadura-L-31 A, B

Polyether type antibiotics are produced by culturing a polyether type antibiotic-producing microorganism in a medium containing a fatty acid or its precursor and ammonia or an ammonium salt or urea.

Method of producing salinomycin antibiotics

SY-1 substance has the following formula: ##STR1## The SY-1 substance and esters and salts thereof are antibiotics which have antibacterial, antifungal, antiviral and anticoccidial activity and also increase feed-utilization efficiency in ruminants.

SY-1 substance

Growing community of inventors

Ageo, Japan

Yukio Miyazaki