Pola Chemical Industries, Inc.

Yukio Kawazu

Masayuki Yuasa

Toshimitsu Suzuki

Takuji Nakashima

Toshiro Majima

Takayuki Namiki

Naoki Hiyama

Akira Nozawa

Masashi Tamai

Satoshi Ichinomiya

Takao Itoh

Mayumi Sugio

Tomoaki Yahiro

Takako Takakuwa

Hiroyuki Takimoto

Kouji Yokoyama

Kenichi Kishii

Mariko Harada

Norio Funayama

Kyoko Taneda

Takao Ito

Yuichi Yokomizo

Amine derivatives

Novel amine derivatives having an excellent antimycotic effect represented by general formula (1) below and salts thereof are provided.

Antifungal amine derivatives and processing for producing the same

The invention relates to a therapeutic and preventive medicament for respiratory diseases, comprising, as an active ingredient, a compound represented by the general formula (1):

Pyrrolo&lsqb;3,2-e&rsqb;pyrazolo&lsqb;1,5-a&rsqb;pyrimidine remedies/preventives for respiratory diseases

This invention relates to compounds represented by the following formula (1): ##STR1## wherein R.sup.1 represents a substituted or unsubstituted phenyl group, R.sup.2 represents a substituted or unsubstituted phenylene group, R.sup.3 represents a substituted or unsubstituted phenyl group or an aliphatic hydrocarbon group containing at least four .pi. electrons, R.sup.4 represents an alkyl group having 1 to 4 carbon atoms, and m and n individually represent integers of from 1 to 4, or salts thereof, and also to compositions containing the same. These compounds have antifungal activities and are useful as drugs.

Antifungal agents

The invention relates to compounds represented by the following general formula (1): ##STR1## wherein R.sup.1 represents an alkyl group, R.sup.2 represents an amino group, alkyl group or the like, and R.sup.3 represents a nitro group, amino group, heterocyclic group, alkylsulfonylamino group or the like, or salts thereof, medicines comprising such a compound, a preparation process of the compounds, and intermediates useful for preparation thereof. The compounds (1) are useful for the prevention and treatment of a respiratory disease.

Pyrrolopyrazolopyrimidine compound and medicine comprising the same as

This invention relates to compounds represented by the following formula (1): ##STR1## wherein R.sup.1 represents a substituted or unsubstituted aromatic hydrocarbon group having 6 to 18 carbon atoms, R.sup.2 represents a hydrogen atom or a substituted or unsubstituted aromatic hydrocarbon group having 6 to 18 carbon atoms, R.sup.3 represents an alkyl group having 1 to 4 carbon atoms, R.sup.4 represents a substituted or unsubstituted phenyl group or an aliphatic hydrocarbon group containing at least four .pi. electrons, and m and n individually represent integers of from 1 to 4, or salts thereof, and also to compositions containing the same. These compounds have antifungal activities and are useful as drugs and the like.

Growing community of inventors

Yokohama, Japan

Yukio Kawazu