Kaken Chemical Co., Ltd.

Other

Kaken Kagaku Kabushiki Kaisha

Yukio Inoue

Makoto Yamamoto

Akira Kawarada

Kazuya Sasaki

Setsuo Takeuchi

Mutsuyuki Kochi

Keiji Sekine

Tsuneo Saita

Shinichiro Esumi

Hajime Shibuya

Shiro Okuda

Kaguya Sasaki

Shozo Kawabata

Makoto Hattori

Disclosed is a novel carcinostatic composition comprising 4,6-0-benzylidene-D-glucopyranose as the active ingredient. This active ingredient exerts a very high carcinostatic activity according to a specific carcinostatic mechanism quite different from that of conventional carcinostatic chemotherapeutic agents. The active ingredient is very low in toxicity and is highly stable and water-soluble. This composition is effective against selected malignant conditions which are carcinoma of the colon, cancer of the stomach, cancer of the tongue, peritonitis carcinomatosa, cancer of the liver and malignancies induced by SV.sub.40 virus.

A composition and method of treating selected malignant conditions

A miticidal method comprises applying a miticidal composition comprising Lysocellin having the formula ##STR1## or its salt or ester.

Miticidal method

Geldanamycin derivatives the following formula ##STR1## wherein R.sup.1 represents a saturated alkylamino which should have at least two carbon atoms, an unsaturated alkylamino, a substituted lower alkylamino, cycloalkylamino, pyrrolidino or aralkylamino group or methoxy group; R.sup.2 represents hydrogen atom, a halogen atom or a lower mono or dialkylamino; when R.sup.1 is methoxy group, R.sup.2 is a halogen atom or lower alkylamino group, or ##STR2## and Geldanamycin derivative is 8,9-epoxy-Geldanamycin. The compounds are effective as antitumor drugs.

Geldanamycin derivatives and antitumor drug

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Tokyo, Japan

Yukio Inoue