Kyowa Hakko Kogyo Co., Ltd.

Yukio Hashimoto

Tadashi Hirata

Ikuo Matsukuma

Takehiro Ogasa

Seigo Takasawa

Shigeru Kobayashi

Shigeo Yoshiie

Kazuo Kimura

Akio Ozaki

Isao Kawamoto

Keiko Ochiai

Akira Sato

Hideki Kawasaki

Kiyoshi Sato

Keishiro Tamura

Keiichi Yano

Kazuo Yamaguchi

Yoshiharu Yokoo

Makoto Yagasaki

Sadao Teshiba

Masaru Hasegawa

Shuichi Ishino

Masaki Azuma

Kazuhisa Iwata

The present invention provides a DNA coding for uricase from the genus Cellulomonas and a process for producing uricase using a microorganism which carries a recombinant DNA containing the DNA.

DNA coding for uricase and process for producing uricase

A novel D-amidase is described. The enzyme specifically hydrolyzes D-.alpha.-alanineamide into D-.alpha.-alanine. It is produced by culturing a microorganism belonging to the genus Arthrobacter, and is useful as an enzyme for efficiently producing D-.alpha.-alanine having a high optical purity and/or L-.alpha.-alanineamide from DL-.alpha.-alanineamide or D-.alpha.-alanineamide at low cost.

D-amidase and process for producing D-.alpha.-alanine and/or

Process for producing D-alpha-alanine and/or L-alpha-alanineamide by

Disclosed are optically active acylated cephalosporin analogs which are useful as antibacterial agents and methods for preparing such compounds.

Optically active carbacephems

Optically active cephalosporin analogs are produced by optically selective deacylation of an optically inactive acylated analog. The compounds are useful as intermediates in the preparation of optically active acylated antimicrobial agents.

Optically active 3-halo carbacephems

Optically active cephalosporin analogs of the formula ##STR1## wherein R.sub.2 represents a hydrogen or a group represented by the formula ##STR2## wherein R.sub.3 is a straight or branched lower alkyl group having 1 to 6 carbon atoms, a straight or branched lower alkoxy group having 1 to 6 carbon atoms or a phenyl group and R.sub.4 is a hydrogen or a straight or branched lower alkyl group having 1 to 6 carbon atoms; and A.sub.2 represents a straight or branched lower alkyl group having 1 to 6 carbon atoms or a straight or branched lower alkyl group having 1 to 6 carbon atoms which is substituted with one or two carboxyl groups, are useful as antibacterial agents.

Optically active cephalosporin analogs

Process for producing optically active cephalosporin analogs

Optically active cephalosporin analogs are produced by an optically selective acylation reaction. The reaction is carried out in the presence of a microbial enzyme which catalyzes the selective optical acylation. The products thus obtained are useful as antibacterial agents.

Process for producing cephalosporin analogs

Disclosed are optically active cephalosporin analogs which are produced by optically selective deacylation of an optically inactive acylated analog. The compounds are useful as intermediates in the preparation of optically active acylated antimicrobial agents.

Process of producing optically active cephalosporin analogs by enzyme

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Yamato, Japan

Yukio Hashimoto