Teikoku Hormone Mfg. Co., Ltd.

Mitsubishi Jidosha Kogyo Kabushiki Kaisha

Teikoku Hormone Manufacturing Co., Ltd.

Yukio Hasegawa

Takashi Mikami

Yasushi Suzuki

Katsuhiko Miyasaka

Norio Yamamoto

Michitaka Sato

Morinobu Saito

Katsuhiko Miyazawa

Nobuyoshi Minami

Kunio Tsukamoto

Satoshi Funakoshi

Nobuo Kijima

Tadaharu Watanabe

Michitaka Satoh

A compound of the formula ##STR1## wherein R.sub.1 is a hydrogen atom or a methoxy group, and A is a C.sub.1 -C.sub.4 alkylene group, or a pharmaceutically acceptable salt thereof. This compound is useful as a medicine, particularly as a lipoxygenase inhibitor for polyunsaturated fatty acids.

2-(3,5-dimethyl-4-hydroxyphenyl)indole derivatives

A compound represented by the formula ##STR1## wherein R.sub.1 represents a lower alkyl group; each of R.sub.2 and R.sub.3 represents an alkyl group having 1 to 3 carbon atoms; and each of R.sub.4, R.sub.5 and R.sub.6 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkanoyloxy group, an aralkyloxy group, a lower alkylthio group, a lower haloalkyl group, a hydroxyl group, a cyano group, a nitro group, an amino group, a mono- or di-(lower alkyl or aralkyl)amino group or a group of the formula ##STR2## in which R.sub.7 represents a lower alkylene group having at least 2 carbon atoms, one of R.sub.8 and R.sub.9 represents a hydrogen atom or a lower alkyl group and the other represents a lower alkyl group, and R.sub.10 represents a hydrogen atom or a lower alkyl group; or any two of R.sub.4, R.sub.5 and R.sub.6 which are adjacent to each other, together, represent a lower alkylenedioxy group, and a salt thereof; and a process for production thereof. This compound has 5-lipoxygenase inhibiting activity and is useful as a medicament.

2-(3,5-dialkyl-4-hydroxyphenyl)indole derivatives

A compound represented by the formula ##STR1## wherein R.sup.1 represents a hydroxyl group, an alkanoyloxy group or a group of the formula ##STR2## in which R.sup.2 represents a hydrogen atom or a lower alkyl group, and R.sup.3 represents a hydrogen atom, a lower alkyl group, an alkanoyl group, a phenyl group, a carbamoyl group or a thiocarbamoyl group, or a salt thereof. The said compound can be prepared by reacting a compound represented by the formula ##STR3## with a compound of the formula

Diphenylmethylimine derivatives, their compositions and pharmaceutical

A positioning device capable of positioning a rod with a first piston fixed thereto into one of four positions selectively by means of a second piston disposed within a chamber A formed in a large-diameter cylinder portion and first, third and fourth pistons disposed within chambers B and C formed in a small-diameter cylinder portion. It is convenient to apply this positioning device to a select mechanism of a transmission or the like having four select positions.

Positioning device

Novel isoquinoline derivatives of the general formula ##STR1## wherein R represents a lower alkyl group, a lower cycloalkyl group, or a group of the formula ##STR2##

1-Phenyl isoquinoline-5-acetic acid compounds and analgesic compositions

Compounds of the general formula ##STR1## or their salts, esters or amide derivatives; and processes for their preparation. In the formula, R.sub.O represents hydrogen or lower alkyl, R.sub.2 represents hydrogen, halogen or nitro, R.sub.3 represents hydrogen or halogen, and R.sub.4 represents hydrogen or lower alkyl; and when R.sub.O is hydrogen, R.sub.2, R.sub.3 and R.sub.4 are all hydrogens and the group ##STR2## is present at the 2-position. These compounds exhibit superior analgesic and/or anti-inflammatory actions with little gastrointestinal troubles.

Growing community of inventors

Yamato, Japan

Yukio Hasegawa