Juridical Foundation the Chemo-sero-therapeutic Research Institute

Yukinobu Tohya

Hiroaki Maeda

Sachio Tokiyoshi

Kazuhiko Kimachi

Kiyoto Nishiyama

Takeshi Mikami

Anti-FCV (feline calicivirus) feline-type recombinant antibody effective for treatment, prevention and diagnosis of FCV infection and a gene fragment useful for preparation of said antibody are provided. Cell line 1D7 capable of producing a mouse monoclonal antibody having an excellent FCV-neutralizing activity was constructed and a gene fragment coding for the V region in charge of the FCV-specific binding of said antibody was obtained. This gene fragment and the gene coding for the constant region of the feline antibody are used to give a chimeric anti-FCV recombinant antibody. The obtained recombinant antibody is a novel antibody and is useful for the diagnosis, treatment and prevention of feline virus infections, particularly feline calicivirus infection, with high safety in administration into cats.

Growing community of inventors

Bunkyo-ku, Japan

Yukinobu Tohya