Eisai R&d Management Co., Ltd.

Yukiko Sugaya

Takashi Kato

Yasuyuki Suzuki

Koichi Ito

Satoshi Nagato

Takao Omae

Itaru Arimoto

Yoshio Urawa

Katsutoshi Nishiura

Hiroyuki Naka

Akio Kayano

Kohshi Ueno

Hiroshi Ishihara

Koji Ukai

Akira Kato

Masaki Ichikawa

The present inventions provide a method for commercially producing a 1,2 -dihydropyridine-2-one compound represented by the following formula (III-a) wherein the ring A represents an optionally substituted 2-pyridyl group, the ring B represents an optionally substituted phenyl group, and the ring C represents an optionally substituted phenyl group. Further, the invention provides crystals of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2 -dihydropyridin-2-one and production processes therefore.

Method for producing 1,2-dihydropyridine-2-one compound

The present inventions provide a method for commercially producing a 1,2-dihydropyridine-2-one compound represented by the following formula (III-a) wherein the ring A represents an optionally substituted 2-pyridyl group, the ring B represents an optionally substituted phenyl group, and the ring C represents an optionally substituted phenyl group. Further, the invention provides crystals of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one and production processes therefore.

Method for producing 1, 2-dihydropyridine-2-one compound

An amorphous form of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridine-2-one.

Amorphous form of 1,2-dihydropyridine compound

An acid addition salt of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one or a hydrate thereof, wherein the acid is selected from the group consisting of benzenesulfonic acid, p-toluenesulfonic acid, hydrochloric acid, hydrobromic acid, sulfuric acid, methanesulfonic acid, fumaric acid, tartaric acid, succinic acid and benzoic acid. 

Salt of 1,2-dihydropyridine compound

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Tsukuba, Japan

Yukiko Sugaya