Immunas Pharma, Inc.

Genox Research, Inc.

Yukiho Imai

Toshiyuki Ito

Tatsuki Yokoseki

Yasuhide Okamoto

Makoto Umeda

Shinobu Fujii

Naofumi Takamatsu

Takeshi Nagasu

Kaoru Ogawa

Yuji Sugita

Keiko Matsui

Nei Yoshida

Tomoko Fujishima

Tadahiro Oshida

Masaya Obayashi

Shigemichi Gunji

Izumi Obayashi

The present inventors successfully produced monoclonal antibodies that are specific to only soluble A beta oligomers, but do not recognize soluble A beta monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.

Antibodies that specifically bind to A beta oligomers and use thereof

Antibodies that specifically bind to a beta oligomers and use thereof

The present inventors successfully produced monoclonal antibodies that are specific to only soluble A beta oligomers, but do not recognize soluble A beta monomers, which are physiological molecules. It was demonstrated that the anti-bodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.

T cells from multiple subjects who showed different cedar pollen specific IgE titers were prepared before and after cedar pollen dispersal, and differential display analysis was performed to screen for pollen antigen responsive genes. As a result, a novel gene was successfully isolated whose expression is significantly higher in subjects with high cedar pollen specific IgE titer. The inventors have found that it is possible to use this gene to test for an allergic disease and to screen for candidate compounds for therapeutic drugs for an allergic disease.

Pollen allergy-related gene 513

Growing community of inventors

Kanagawa, Japan

Yukiho Imai