Kyowa Hakko Kirin Co., Limited

Yukihito Tsukumo

Kyoichiro Iida

Nobumasa Otsubo

Shuko Okazaki

Kenji Uchida

Michihiko Suzuki

Takeshi Kuboyama

Hitoshi Arai

Masahiro Matsubara

Kimihisa Ueno

Arata Yanagisawa

Kozo Yao

Seiji Aratake

Kazuki Hemmi

Masayoshi Nakoji

Akinori Hamaguchi

Takamichi Imaizumi

Fumitake Takizawa

Yuichi Matsumoto

Provided are a compound represented by general formula (I), or the pharmaceutically acceptable salt thereof, (wherein Rrepresents a hydrogen atom or the like, Rand Rmay be the same or different, and each represents a hydrogen atom, optionally substituted lower alkyl or cycloalkyl, or Rand Rare combined together with the adjacent nitrogen atom thereto to form nitrogen-containing heterocyclic group, and Z represents a bicyclic heterocyclic group in which optionally substituted two six-membered rings are fused to each other, or the like) and the like.

Pyrimidodiazepinone compound

The present invention provides a PPAR &#x3b3; agonist comprising, as an active ingredient, a tricyclic compound represented by the formula (I) (wherein Rrepresents lower alkyl optionally having substituent(s) or the like, Rand Rare the same or different and each represents lower alkyl optionally having substituent(s) or the like, Rand Rare the same or different and each represents a hydrogen atom or the like, Q-Q-Qrepresents CH&#x2550;CH&#x2014;CH&#x2550;CH or the like, Y represents a single bond or the like, Z-Zrepresents C&#x2550;CR(wherein Rrepresents a hydrogen atom or the like), or the like, and A represents &#x2014;COOH or the like), or a pharmaceutically acceptable salt thereof and the like.

Tricyclic compounds

The invention provides a pyrimidodiazepinone derivative represented by the general formula (I) [wherein n represents 1 or 2, Z represents a hydrogen atom or the like, Rand Rmay be the same or different, and each represents a hydrogen atom or the like, A represents a bond, (CH)(wherein m represents an integer of 1 to 4), optionally substituted phenylene, optionally substituted pyridinediyl, or C&#x2550;O, Rrepresents a hydrogen atom, optionally substituted lower alkyl, or the like, and Rrepresents a hydrogen atom or the like], or a pharmaceutically acceptable salt thereof or the like.

Pyrimidodiazepinone derivative

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Shizuoka, Japan

Yukihito Tsukumo