Teikoku Seiyaku Co., Ltd.

Lederle (japan), Ltd.

Teikoku Seiyaku Kabushiki Kaisha

Yukihiro Tada

Takahiko Wato

Nobuko Inoue

Teruo Hama

Akihito Oji

Noriyuki Sasaki

Mitsuo Mizumura

Shin-ichi Hisaichi

A preparation for intermittently releasing an active agent which comprises a laminated combination of a release-controlling layer and a pharmaceutically active agent-containing layer wherein one or more of pharmaceutically active agent layers are incorporated into said release-controlling layer. The preparation in accordance with the present invention can intermittently control the release of the active agent to decrease a dosage time and is applicable to the mucous membrane or gingivae within the oral cavity.

Preparation for intermittently releasing active agent applicable to oral

An anti-inflammatory analgesic patch having a drug reservoir layer comprising 4-biphenylylacetic acid as the effective ingredient, a homo- and/or co-polymer of acrylic acid and ordinary adjuvants such as a shape-retaining agent, humectant, thickener, etc., which is characterized in that said drug reservoir further contains crotamiton and pH of the drug reservoir is adjusted within a range of 6 to 8 with a water-soluble organic amine and an organic acid.

Anti-inflammatory analgesic patch

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Takamatsu, Japan

Yukihiro Tada