Kowa Company Limited

Yukihiro Okuno

Yoshio Takahashi

Masami Shiratsuchi

Toshiaki Oda

Hiroyuki Ishiwata

Takeo Deushi

Takashi Yamaguchi

Seiichi Sato

Kimiyuki Shibuya

Tadaaki Ohgiya

Yoshinori Kyotani

Hiromichi Shigyo

Kazuhiro Onogi

Yasumi Uchida

Tsutomu Toma

Masahito Nakayama

Katsumi Kawamine

Tomio Ohta

Noboru Shimizu

Hisakatsu Itoh

Katsuhiro Yamamoto

Mikio Fujii

Azoxy compound

An indole derivative represented by formula (1), ##STR1## wherein A is a group ##STR2## wherein R.sup.10 is hydrogen or lower alkyl, dotted lines may optionally be present, and R.sup.1 -R.sup.9 represents various substitutional groups. The compound (1) exhibits a positive inotropic action on cardiac muscle, an anti-arrhythmic action, and a vasodilation action without increasing the heart rate. A heart affection therapeutic agent comprising this compound as an effective component is extremely effective for treating heart failures and arrhythmia.

Indole derivatives, salts thereof, and congestive heart failure

A compound expressed by the formula: ##STR1## in which R.sub.11, R.sub.21 and R.sub.31 are identical with or different from each other and each denotes a hydrogen atom, a halogen atom, an alkyl group, an alkenyl group, a haloalkyl group, an alkoxy group, an alkylthio group, an aryl or an aralkyl group which aromatic ring is optionally substituted appropriately by one to three substituents or a heterocyclic group optionally substituted appropriately by one to three substituents, or R.sub.11 and R.sub.21 may together form an alkylene group, Y denotes O or NOH, with a proviso that where R.sub.21 (or R.sub.11) and R.sub.31 denote a hydrogen atom at the same time, R.sub.11 (or R.sub.21) cannot represent an n-butyl group. This compound is useful as an antifungal agent.

Azoxy compounds

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Higashimurayama, Japan

Yukihiro Okuno