Wakunaga Seiyaku Kabushiki Kaisha

Wakunaga Pharmaceutical Co., Ltd.

Yukihiro Kodera

Hiromichi Matsuura

Yoichi Itakura

Mitsuyasu Ushijima

Naoaki Morihara

Junichiro Suzuki

Shoji Awazu

Toshiharu Horie

Shinji Nagae

Kenji Itoh

Susumu Yoshida

Hoyoku Nishino

Kayo Kunimura

Satomi Miki

Toshiaki Matsutomo

Miyuki Takashima

Toshihiko Sumida

To provide a compound used for activating autophagy, which has few side effects and mild effects comprising S1PC or a salt thereof as an active ingredient.

Autophagy activating agent

Provided is a blood flow improver which is safe and has a mild action. The blood flow improver comprises S-1-propenylcysteine or a salt thereof as an active ingredient.

Blood flow improver

Provided is an antihypertensive agent that is safe and has a mild effect. An antihypertensive agent comprising S-1-propenylcysteine or a salt thereof as an active ingredient.

Antihypertensive agent

An immunomodulator useful for modulating immune function and maintaining intravital homeostasis is provided. The immunomodulator comprises S-1-propenycysteine or a salt thereof as an active ingredient.

Immunomodulator

A lipid peroxidation inhibitor contains a polysulfide compound represented by formula (I) as an active ingredient:

Polysulfides compounds and lipid peroxidation inhibitor containing the

An Allium genus plant, typically garlic is extracted by adding water or alcohol to the garlic, subjecting a mixture of the solvent and the garlic to extraction, and collecting an extract liquid. A composition containing S-allylcysteine in the extract liquid from the garlic is obtained by adding cysteine to the solvent, the mixture of the solvent and the plant under extraction, or the extract liquid collected, and causing the cysteine to convert into S-allylcysteine which is effective controlling hepatopathy and oncogenesis.

Method for preparing an S-allylcysteine-containing composition

Heterocyclic compounds of the general formula: ##STR1## wherein R.sup.11 is a hydroxyl group or a lower alkoxy group, R.sup.12 is a lower alkoxy group, R.sup.13 is a saturated or unsaturated hydrocarbon group, X is an oxygen atom or a sulfur atom, and Y is an oxygen atom or --NH-- which may have a lower alkyl substituent, or salts thereof are novel and effective in controlling carcinoma.

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Hiroshima, Japan

Yukihiro Kodera